Inhibition of long-term potentiation in developing rat visual cortex but not hippocampus by in utero exposure to polychlorinated biphenyls
| Autor: | Hellmuth Lilienthal, Herbert Wiegand, Lilo Altmann, Jürgen Hany |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Aging
medicine.medical_specialty Long-Term Potentiation Hippocampus Hippocampal formation Biology chemistry.chemical_compound fluids and secretions Developmental Neuroscience Pregnancy Internal medicine medicine Animals Rats Long-Evans reproductive and urinary physiology Visual Cortex organic chemicals Neurotoxicity food and beverages Polychlorinated biphenyl Long-term potentiation medicine.disease Polychlorinated Biphenyls Electric Stimulation Rats stomatognathic diseases Congener Endocrinology Visual cortex medicine.anatomical_structure chemistry In utero Prenatal Exposure Delayed Effects Female Neuroscience Developmental Biology |
| Zdroj: | Developmental Brain Research. 110:257-260 |
| ISSN: | 0165-3806 |
| Popis: | The neurotoxic potential of polychlorinated biphenyls (PCBs) depends on the structure of the congener as well as on the age of the exposure. We exposed rats prenatally to a coplanar congener (PCB-77) or to a non-coplanar congener (PCB-47) and measured the amount of long-term potentiation (LTP) at postnatal days 11–19 in the visual cortex and hippocampus. While PCB-77 exposure affected LTP statistically significantly in cortical but not hippocampal slices, the exposure to PCB-47 was much less effective. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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