Risk of bronchopulmonary dysplasia by second-trimester maternal serum levels of α-fetoprotein, human chorionic gonadotropin, and unconjugated estriol
| Autor: | Laura L. Jelliffe-Pawlowski, Rebecca J. Baer, Robert Currier, Jeffrey B. Gould, David K. Stevenson, Hugh O'Brodovich, Cele Quaintance, Gary M. Shaw, Allan J. Santos, John Oehlert |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Risk endocrine system medicine.medical_specialty Adolescent Chorionic Gonadotropin Article Human chorionic gonadotropin 03 medical and health sciences 0302 clinical medicine Unconjugated estriol Pregnancy Second trimester 030225 pediatrics Internal medicine mental disorders medicine Humans reproductive and urinary physiology Bronchopulmonary Dysplasia Inflammation 030219 obstetrics & reproductive medicine Estriol business.industry Infant Newborn medicine.disease Infant newborn digestive system diseases Endocrinology Bronchopulmonary dysplasia Pregnancy Trimester Second embryonic structures Pediatrics Perinatology and Child Health Regression Analysis Female alpha-Fetoproteins business Biomarkers hormones hormone substitutes and hormone antagonists |
| Zdroj: | Pediatric research |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1038/pr.2011.73 |
| Popis: | Although maternal serum alpha-fetoprotein (AFP), human chorionic gonandotrophin (hCG), and estriol play important roles in immunomodulation and immunoregulation during pregnancy, their relationship to the development of bronchopulmonary dysplasia (BPD) in young infants is unknown despite BPD being associated with pre- and postnatal inflammatory factors. The objective of this population-based study was to examine whether second trimester levels of AFP, hCG, and unconjugated estriol (uE3) were associated with an increased risk of BPD. We found that these serum biomarkers were associated with an increased risk of BPD. Risks were especially high when AFP and/or hCG levels were above the 95th percentile and/or when uE3 levels were below the 5th percentile (relative risks (RRs) 3.1 to 6.7). Risks increased substantially when two or more biomarker risks were present (RRs 9.9 to 75.9). Data suggested that pregnancies which had a biomarker risk and yielded an offspring with BPD were more likely to have other factors present that suggested early intrauterine fetal adaptation to a stress including maternal hypertension and asymmetric growth restriction. |
| Databáze: | OpenAIRE |
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