Midodrine prevents orthostatic intolerance associated with simulated spaceflight
| Autor: | Gordon H. Williams, Ramakrishna Mukkamala, Daniel M. Bloomfield, Janice Yelle, Thomas J. Mullen, Richard J. Cohen, Derin A. Sherman, Nikolai Aljuri, Ming Maa, Karin Toska, Natalie Sheynberg, Grete H. Sundby, Craig D. Ramsdell, Siri Rostoft |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male medicine.medical_specialty Physiology medicine.medical_treatment Midodrine Orthostatic intolerance Spaceflight Bed rest law.invention Hypotension Orthostatic Tilt table test Physical medicine and rehabilitation Tilt-Table Test law Physiology (medical) Humans Medicine Presyncope medicine.diagnostic_test business.industry Weightlessness Hemodynamics Space medicine medicine.disease Surgery Autonomic Nervous System Diseases business Adrenergic alpha-Agonists Bed Rest Space Simulation medicine.drug |
| Zdroj: | Journal of Applied Physiology. 90:2245-2248 |
| ISSN: | 1522-1601 8750-7587 |
| Popis: | Many astronauts after being weightless in space become hypotensive and presyncopal when they assume an upright position. This phenomenon, known as orthostatic intolerance, may interfere with astronaut function during reentry and after spaceflight and may limit the ability of an astronaut to exit a landed spacecraft unaided during an emergency. Orthostatic intolerance is more pronounced after long-term spaceflight and is a major concern with respect to the extended flights expected aboard the International Space Station and for interplanetary exploration class missions, such as a human mission to Mars. Fully effective countermeasures to this problem have not yet been developed. To test the hypothesis that α-adrenergic stimulation might provide an effective countermeasure, we conducted a 16-day head-down-tilt bed-rest study (an analog of weightlessness) using normal human volunteers and administered the α1-agonist drug midodrine at the end of the bed-rest period. Midodrine was found to significantly ameliorate excessive decreases in blood pressure and presyncope during a provocative tilt test. We conclude that midodrine may be an effective countermeasure for the prevention of orthostatic intolerance following spaceflight. |
| Databáze: | OpenAIRE |
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