Consequences of a screening programme on the prevalence of congenital hereditary sensorineural deafness in the Australian Cattle Dog

Autor:	John M. Morton, S. F. Sommerlad, Jennifer M. Seddon, I. Johnstone, C. A. O'Leary
Rok vydání:	2014
Předmět:	Pediatrics medicine.medical_specialty Animal breeding Australian cattle dog Hearing Loss Sensorineural biology.animal_breed Prevalence Pedigree chart Biology Breeding Selective breeding Dogs Genetics medicine Evoked Potentials Auditory Brain Stem Animals Dog Diseases Longitudinal Studies Retrospective Studies Australia Grandparent General Medicine Odds ratio Pedigree Auditory brainstem response Logistic Models Phenotype Animal Science and Zoology
Zdroj:	Animal genetics. 45(6)
ISSN:	1365-2052
Popis:	Genetic disease testing programmes are used in domestic animal breeds to guide selective breeding with the aim of reducing disease prevalence. We assessed the change in the prevalence of canine congenital hereditary sensorineural deafness (CHSD) in litters of Australian Cattle Dogs following the introduction of a brainstem auditory evoked response (BAER) testing programme. We studied 608 pups from 122 litters from 10 breeding kennels. Despite 10 years of testing (1998-2008), no substantial reduction in prevalence of CHSD was evident in these 10 breeding kennels. Even for the subset of litters in which both parents were BAER tested as normal hearing (305 pups from 58 litters), there was no evidence of substantial reduction in prevalence. Odds ratios for CHSD in pups for each extra year since testing in the kennel commenced were 1.01 (95% CI, 0.88-1.17) and 1.03 (95% CI, 0.82-1.30) respectively for these populations. Amongst 284 dogs from 54 litters with extended pedigrees and both parents BAER-tested normal hearing, observed prevalences of CHSD were highest in pups with no BAER-tested normal grandparents (17% or 5/29) and lowest in pups with all four grandparents tested normal (0% or 0/9). In pups for which one, two and three grandparents tested negative, prevalences of CHSD were 12% (9/74), 9% (9/101) and 8% (6/71) respectively. Hence, testing programmes based on phenotypic screening may not lead to a substantial reduction in recessive genetic disease prevalence over the medium term, even when only tested normal parents are used. Exclusive breeding of litters in which both parents and all four grandparents are BAER-tested normal is expected to reduce CHSD prevalence in pups to the greatest extent over the long term.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f190c66a6dd3be074f7d5fc8a942dbec https://pubmed.ncbi.nlm.nih.gov/25286978 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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