Association between dopamine and somatostatin receptor expression and pharmacological response to somatostatin analogues in acromegaly

Autor: Raúl M. Luque, Mari C Vázquez-Borrego, Miguel A. Japón, Elena Dios, Alvaro Flores-Martínez, David A. Cano, Noelia Gros-Herguido, Justo P. Castaño, Eva Venegas-Moreno, Esther Rivero-Cortés, Alfonso Soto-Moreno, Ainara Madrazo-Atutxa
Přispěvatelé: [Venegas-Moreno, Eva] Univ Seville, CSIC, Hosp Univ Virgen del Rocio, Unidad Gest Endocrinol Nutr,Inst Biomed Sevilla I, Seville, Spain, [Dios, Elena] Univ Seville, CSIC, Hosp Univ Virgen del Rocio, Unidad Gest Endocrinol Nutr,Inst Biomed Sevilla I, Seville, Spain, [Gros-Herguido, Noelia] Univ Seville, CSIC, Hosp Univ Virgen del Rocio, Unidad Gest Endocrinol Nutr,Inst Biomed Sevilla I, Seville, Spain, [Flores-Martinez, Alvaro] Univ Seville, CSIC, Hosp Univ Virgen del Rocio, Unidad Gest Endocrinol Nutr,Inst Biomed Sevilla I, Seville, Spain, [Madrazo-Atutxa, Ainara] Univ Seville, CSIC, Hosp Univ Virgen del Rocio, Unidad Gest Endocrinol Nutr,Inst Biomed Sevilla I, Seville, Spain, [Cano, David A.] Univ Seville, CSIC, Hosp Univ Virgen del Rocio, Unidad Gest Endocrinol Nutr,Inst Biomed Sevilla I, Seville, Spain, [Soto-Moreno, Alfonso] Univ Seville, CSIC, Hosp Univ Virgen del Rocio, Unidad Gest Endocrinol Nutr,Inst Biomed Sevilla I, Seville, Spain, [Vazquez-Borrego, Mari C.] Univ Cordoba, Agrifood Campus Int Excellence CeiA3, CIBER Physiopathol Obes & Nutr CIBERobn,Dept Cell, Maimonides Inst Biomed Res Cordoba IMIBIC,Rein So, Cordoba, Spain, [Rivero-Cortes, Esther] Univ Cordoba, Agrifood Campus Int Excellence CeiA3, CIBER Physiopathol Obes & Nutr CIBERobn,Dept Cell, Maimonides Inst Biomed Res Cordoba IMIBIC,Rein So, Cordoba, Spain, [Luque, Raul M.] Univ Cordoba, Agrifood Campus Int Excellence CeiA3, CIBER Physiopathol Obes & Nutr CIBERobn,Dept Cell, Maimonides Inst Biomed Res Cordoba IMIBIC,Rein So, Cordoba, Spain, [Castano, Justo P.] Univ Cordoba, Agrifood Campus Int Excellence CeiA3, CIBER Physiopathol Obes & Nutr CIBERobn,Dept Cell, Maimonides Inst Biomed Res Cordoba IMIBIC,Rein So, Cordoba, Spain, [Japon, Miguel A.] Univ Seville, CSIC, Hosp Univ Virgen del Rocio, Dept Pathol,Inst Biomed Sevilla IBIS, Seville, Spain, ISCIII-Subdireccion General de Evaluacion y Fomento de la Investigacion, Fondos FEDER, Novartis Oncology Spain, Junta de Andalucia, MINECO, CIBERobn (CIBER is an initiative of Instituto de Salud Carlos III, Ministerio de Sanidad, Servicios Sociales e Igualdad, Spain), Novartis Oncology, Andalusian and Spanish Societies of Endocrinology and Nutrition (SAEDYN), Andalusian and Spanish Societies of Endocrinology and Nutrition (SEEN), 'Nicolas Monardes' programme of the Andalusian Ministry of Health
Rok vydání: 2017
Předmět:
Male
Octreotide-lar
Gene Expression
pituitary adenoma
Receptors
Dopamine
In-vitro
0302 clinical medicine
Subtype 2a
dopamine receptor
Protein Isoforms
Somatostatin receptor 2
Pituitary-adenomas
Somatostatin receptor 1
Receptors
Somatostatin
Receptor
Somatotroph adenomas
somatostatin analogues
Reverse Transcriptase Polymerase Chain Reaction
Somatostatin receptor
Middle Aged
Immunohistochemistry
somatostatin receptor
Somatostatin
Biochemical response
Dopamine receptor
030220 oncology & carcinogenesis
Molecular Medicine
Original Article
Female
Adenoma
Adult
medicine.medical_specialty
Monoclonal-antibodies
030209 endocrinology & metabolism
03 medical and health sciences
Pituitary adenoma
Internal medicine
Acromegaly
medicine
Humans
Retrospective Studies
Tumor-cells
business.industry
Original Articles
Cell Biology
medicine.disease
Endocrinology
acromegaly
Clinical-response
Growth Hormone-Secreting Pituitary Adenoma
Aggressive features
business
Zdroj: Journal of Cellular and Molecular Medicine
ISSN: 1582-1838
Popis: Acromegaly is a hormonal disorder resulting from excessive growth hormone (GH) secretion frequently produced by pituitary adenomas and consequent increase in insulin‐like growth factor 1 (IGF‐I). Elevated GH and IGF‐I levels result in a wide range of somatic, cardiovascular, endocrine, metabolic and gastrointestinal morbidities. Somatostatin analogues (SSAs) form the basis of medical therapy for acromegaly and are currently used as first‐line treatment or as second‐line therapy in patients undergoing unsuccessful surgery. However, a considerable percentage of patients do not respond to SSAs treatment. Somatostatin receptors (SSTR1‐5) and dopamine receptors (DRD1‐5) subtypes play critical roles in the regulation of hormone secretion. These receptors are considered important pharmacological targets to inhibit hormone oversecretion. It has been proposed that decreased expression of SSTRs may be associated with poor response to SSAs. Here, we systematically examine SSTRs and DRDs expression in human somatotroph adenomas by quantitative PCR. We observed an association between the response to SSAs treatment and DRD4, DRD5, SSTR1 and SSTR2 expression. We also examined SSTR expression by immunohistochemistry and found that the immunohistochemical detection of SSTR2 in particular might be a good predictor of response to SSAs.
Databáze: OpenAIRE
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