Impact of age at menarche on obesity and glycemic control in Japanese patients with type 2 diabetes: Fukuoka Diabetes Registry
| Autor: | Hitoshi Ide, Akiko Sumi, Yuji Komorita, Tamaki Jodai-Kitamura, Toshiaki Ohkuma, Udai Nakamura, Masahito Yoshinari, Takanari Kitazono, Masanori Iwase, Hiroki Fujii |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Pediatrics Endocrinology Diabetes and Metabolism Type 2 diabetes Body Mass Index 0302 clinical medicine Glycemic control Japan Risk Factors 030212 general & internal medicine Prospective Studies Registries Child Abdominal obesity Age at menarche Incidence Age Factors General Medicine Articles Middle Aged Prognosis Clinical Science and Care Menarche Female Original Article medicine.symptom Adult medicine.medical_specialty Adolescent 030209 endocrinology & metabolism 03 medical and health sciences Young Adult Type 2 diabetes mellitus Internal Medicine medicine Humans Obesity Glycemic Aged Retrospective Studies business.industry Type 2 Diabetes Mellitus Odds ratio medicine.disease Hypoglycemia Diabetes Mellitus Type 2 Hyperglycemia business Body mass index Biomarkers Follow-Up Studies |
| Zdroj: | Journal of Diabetes Investigation |
| ISSN: | 2040-1124 |
| Popis: | Aims/Introduction A younger age at menarche is associated with obesity and type 2 diabetes in adult life. The impact of early‐onset menarche on obesity and glycemic control in type 2 diabetes has not been investigated. The present study examined the relationship between age at menarche and obesity and glycemic control in type 2 diabetes. Materials and Methods A total of 2,133 patients with type 2 diabetes aged ≥20 years were divided into groups according to age at menarche (≤11, 12, 13, 14 and ≥15 years). A retrospective cohort study examined the association of menarcheal age with adiposity and hemoglobin A1c. Results Age at menarche was inversely associated with body mass index (BMI) and abdominal circumference (P < 0.001). Each 1‐year decrease in age at menarche was associated with a 0.25‐kg/m2 and 0.6‐cm increase in BMI and abdominal circumference, respectively, using a multivariate‐adjusted model. Odds ratios for obesity and abdominal obesity significantly increased in participants with age at menarche ≤11 years after multivariable adjustments when age at menarche of 13 years was used as the reference (odds ratio 1.95, 95% CI 1.33–2.88, odds ratio 1.95, 95% CI 1.32–2.87, respectively). Younger age at menarche was significantly associated with higher hemoglobin A1c (P < 0.001); however, the association was not statistically significant after adjusting for BMI. Conclusions Age at menarche of ≤11 years was associated with obesity after adjusting for confounding factors, and poor glycemic control associated with high BMI in type 2 diabetes. Age at menarche should be considered during clinical assessments. |
| Databáze: | OpenAIRE |
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