Evaluation of SOX2 and podoplanin expression in oral epithelial dysplasia and its correlation with malignant transformation
| Autor: | Chetana Chandrashekar, Vani Verma |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Epithelial dysplasia
medicine.disease_cause Malignant transformation 03 medical and health sciences 0302 clinical medicine SOX2 Cancer stem cell medicine Biomarkers Tumor Humans Membrane Glycoproteins business.industry SOXB1 Transcription Factors Cancer 030206 dentistry General Medicine medicine.disease Cell Transformation Neoplastic Podoplanin Dysplasia 030220 oncology & carcinogenesis Cancer research Carcinoma Squamous Cell Mouth Neoplasms Carcinogenesis business |
| Zdroj: | Journal of investigative and clinical dentistryREFERENCES. 10(4) |
| ISSN: | 2041-1626 |
| Popis: | Aim Oral carcinogenesis cascade is a complex process, characterized by variable numbers of genetic and epigenetic alterations of various genes with manifold roles that could serve as biological hallmarks. This study was undertaken to assess the protein expression of SOX2 and podoplanin in oral epithelial dysplasia and correlate the expression with clinicopathological parameters and risk of malignant transformation. Methods SOX2 and podoplanin expression were analyzed in 60 cases of oral epithelial dysplasia. The association between SOX2 and podoplanin expression with various clinicopathological parameters and transformation to oral cancer was analyzed. Results A higher Histoscore was seen in 55% of moderate and 30% of severe dysplasia. 25% of the cases showed a negative podoplanin expression and 30% of patients had higher podoplanin expression (score 2 and 3). Though there was significant association of both SOX2 and podoplanin expression with the degree of dysplasia, the association of their expression with transformation to oral squamous cell carcinoma did not reach statistical significance. Conclusion Alteration in SOX2 and podoplanin is likely an important event in head and neck carcinogenesis; however, their expression may be valuable only in a few cases of oral epithelial dysplasia to assess the risk of malignant transformation. |
| Databáze: | OpenAIRE |
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