Spontaneous pathological complete regression of high-grade triple-negative breast cancer with axillary metastasis
| Autor: | László Markó, Gábor Cserni, Orsolya Serfozo, László Krenács, Éva Ambrózay |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Pathology
medicine.medical_specialty Stromal cell Biopsy Fine-Needle lcsh:Medicine Triple Negative Breast Neoplasms B7-H1 Antigen spontaneous regression Pathology and Forensic Medicine Immune system Lymphocytes Tumor-Infiltrating pd-l1 PD-L1 Biopsy Medicine Cytotoxic T cell Humans tumour-infiltrating lymphocytes Triple-negative breast cancer Aged medicine.diagnostic_test biology business.industry Carcinoma lcsh:R General Medicine Granzyme B Lymphatic Metastasis biology.protein triple-negative breast cancer Female Biopsy Large-Core Needle business Breast carcinoma T-Lymphocytes Cytotoxic |
| Zdroj: | Polish Journal of Pathology, Vol 70, Iss 2, Pp 139-143 (2019) |
| ISSN: | 2084-9869 1233-9687 |
| Popis: | We report on a breast carcinoma with medullary features diagnosed by core needle biopsy in a 72-year-old woman. Both the primary tumour and its fine needle aspiration-proven, rapidly growing axillary metastasis regressed completely in less than 2 months, by the time surgery was performed. The biopsy of the primary tumour demonstrated a dense stromal infiltrate of CD8+/granzyme B+ activated cytotoxic T-cells suggestive of a robust antitumour immune response. Paradoxically, both tumour cells and tumour infiltrating immune cells demonstrated a diffuse PD-L1 expression, revealing that antitumour immune response has the ability to spontaneously overcome inhibitory mechanisms induced by cancerous growth. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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