Five new cassane diterpenes from the seeds and bark of Erythrophleum suaveolens
| Autor: | Mehdi A. Beniddir, Gustav Komlaga, Koffi Barthélemy Attioua, Faustin Aka Kabran, Blandine Séon-Méniel, Adrien Jagora, Pierre Le Pogam, Ballo Daouda, Jacques Dibi Konan, Pierre Champy, Karine Leblanc, Ahmont Claude Landry Kablan, Tapé Kouamé, Amon Diane N'Tamon |
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| Přispěvatelé: | Université Péléforo Gon Coulibaly (UPGC), Laboratoire de Chimie des Substances Naturelles (LCSN), Université de Limoges (UNILIM)-Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503), Biomolécules : Conception, Isolement, Synthèse (BioCIS), Institut de Chimie du CNRS (INC)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-CY Cergy Paris Université (CY), Kwame Nkrumah University of Science and Technology [GHANA] (KNUST) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Stereochemistry
[SDV]Life Sciences [q-bio] Phytochemicals 01 natural sciences chemistry.chemical_compound Cell Line Tumor Drug Discovery Humans Sugar Pharmacology Molecular Structure biology 010405 organic chemistry Fabaceae General Medicine biology.organism_classification Antineoplastic Agents Phytogenic Terpenoid 0104 chemical sciences 010404 medicinal & biomolecular chemistry Cote d'Ivoire chemistry visual_art Erythrophleum suaveolens Seeds Plant Bark visual_art.visual_art_medium Bark Diterpenes Diterpene Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | Fitoterapia Fitoterapia, Elsevier, 2020, 146, pp.104700-. ⟨10.1016/j.fitote.2020.104700⟩ |
| ISSN: | 0367-326X 1873-6971 |
| Popis: | Five new cassane-type diterpenoid heterosides, i. e. two cassane-type amides (1-2), two erythrophlamine-type amine esters (3-4) and a non‑nitrogenous erythrophlamine analogue (5) were isolated from the root barks (1-2) and the seeds (3-5) of Erythrophleum suaveolens. Their structures were unambiguously established by interpretation of their HRESIMS, 1D and 2D NMR data, and chemical degradation for sugar determination. Compounds 3-5 were evaluated for their cytotoxicity against a panel of three cell lines, revealing modest to strong activities. |
| Databáze: | OpenAIRE |
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