Prevalence of vitamin D depletion among morbidly obese patients seeking gastric bypass surgery
| Autor: | Gary B. Talpos, D. Sudhaker Rao, Arthur M. Carlin, Jeffrey A. Genaw, Ali M. Meslemani, Arti Bhan, Nayana Parikh, Shiri Levy |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Gastric Bypass Parathyroid hormone chemistry.chemical_element Morbidly obese Calcium medicine.disease_cause Prevalence Vitamin D and neurology medicine Humans Prospective Studies Vitamin D Aged Chi-Square Distribution business.industry Gastric bypass surgery Middle Aged Alkaline Phosphatase Vitamin D Deficiency medicine.disease Obesity Morbid Surgery chemistry Parathyroid Hormone Linear Models Alkaline phosphatase Female Secondary hyperparathyroidism business Body mass index |
| Zdroj: | Surgery for Obesity and Related Diseases. 2:98-103 |
| ISSN: | 1550-7289 |
| DOI: | 10.1016/j.soard.2005.12.001 |
| Popis: | Abnormalities in calcium and vitamin D metabolism have been reported after bariatric surgery. The purpose of this study was to evaluate vitamin D nutritional status among morbidly obese patients before gastric bypass surgery.We prospectively studied 279 morbidly obese patients seeking gastric bypass surgery for vitamin D nutritional status as assessed by serum 25-hydroxyvitamin D level. In addition, serum samples were analyzed for calcium, alkaline phosphatase (AP), intact parathyroid hormone (PTH), and 1,25-dihydroxyvitamin D.Mean patient age was 43 +/- 9 years; 87% of the study patients were women, and 72% were white. Serum calcium and AP levels were normal in 88% and 89% of the patients, respectively. Vitamin D depletion, defined as serum 25-hydroxyvitamin D levelor= 20 ng/mL, was found in 166 patients (60%). An elevated PTH level was found in 48% of the patients. A significant inverse correlation was found between serum 25-hydroxyvitamin D level and both body mass index (r = .15; P = .012) and serum PTH level (r = .45; P.001). Vitamin D depletion was significantly more prevalent in the African-American patients than in the white patients (91% vs 48%; P.001).Before gastric bypass surgery, a majority of morbidly obese patients have vitamin D depletion and secondary hyperparathyroidism. Studies evaluating the effects of gastric bypass on vitamin D metabolism must consider preoperative vitamin D nutritional status. |
| Databáze: | OpenAIRE |
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