Antitumoral activity of 1,2,4-oxadiazoles compounds isolated from the Neowerdermannia vorwerkii in liver and colon human cancer cells

Autor:	Luis Apaza Ticona, Ángel Rumbero Sánchez, Marcos Humanes Bastante, Andreea Madalina Serban, María J. Hernáiz
Rok vydání:	2022
Předmět:	Oxadiazoles Structure-Activity Relationship Magnetic Resonance Spectroscopy Liver Colon Neoplasms Humans Plant Science General Medicine Caco-2 Cells Horticulture Molecular Biology Biochemistry
Zdroj:	Phytochemistry. 201:113259
ISSN:	0031-9422
DOI:	10.1016/j.phytochem.2022.113259
Popis:	Two unknown 1,2,4-oxadiazoles (3-(pyridin-3-yl)-5-(thiophen-3-yl)-1,2,4-oxadiazole and 5-(3-hydroxyphenyl)-3-(pyridin-3-yl)-1,2,4-oxadiazole) and one known 1,2,4-oxadiazole (5-(3-methoxyphenyl)-3-(pyridin-3-yl)-1,2,4-oxadiazole) were isolated from tubers of Neowerdermannia vorwerkii, collected from the San Juan Huancollo, Ingavi province, La Paz, Bolivia. The chemical structures of these compounds were elucidated through NMR and HRMS spectroscopic analyses. All compounds showed apoptotic capacity against the SK-HEP-1 and Caco-2 tumour cells. 5-(3-methoxyphenyl)-3-(pyridin-3-yl)-1,2,4-oxadiazole and 5-(3-hydroxyphenyl)-3-(pyridin-3-yl)-1,2, 4-oxadiazole showed slight apoptotic capacities, with an IC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f186b79105a496a75b9ee8de93f9b9c3 https://doi.org/10.1016/j.phytochem.2022.113259 Zobrazit plný text záznamu Full Text from ScienceDirect