Increased incidence of acute nonlymphocytic leukemia following therapy in patients with small cell carcinoma of the lung
| Autor: | Richard S. Cox, Linda Y. Chak, M A Tucker, Branimir I. Sikic, R C Horns |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Adult
Male Risk Cancer Research medicine.medical_specialty Pathology Lung Neoplasms Time Factors medicine.medical_treatment Small-cell carcinoma Gastroenterology Random Allocation Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Carcinoma Small Cell Aged Leukemia Radiation-Induced Clinical Trials as Topic Acute leukemia Leukemia Lung Radiotherapy business.industry Incidence (epidemiology) Middle Aged medicine.disease Combined Modality Therapy Confidence interval Radiation therapy medicine.anatomical_structure Oncology Relative risk Female business |
| Zdroj: | Journal of Clinical Oncology. 2:385-390 |
| ISSN: | 1527-7755 0732-183X |
| DOI: | 10.1200/jco.1984.2.5.385 |
| Popis: | A group of 158 patients with small cell carcinoma of the lung were followed for 174.5 person-years of observation to determine the risk of acute leukemia. Three cases of acute nonlymphocytic leukemia were observed at 2.3, 2.7, and 3.0 years. The relative risk of developing leukemia was 316 (95% confidence limit, 76-818) and the actuarial risk was 25% +/- 13% at 3.1 years. The relative risk for leukemia was significantly increased in these patients (p less than 0.0001). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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