An Unusual Case of Diffuse Alveolar Hemorrhage as a Clinical Manifestation of Atypical Hemolytic Uremic Syndrome: A Case Report
| Autor: | Omar Abughanimeh, Ahmad Al-Shyoukh, Mohammad Tahboub, Moustafa Younis, Majdi Hamarshi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Hemolytic anemia
medicine.medical_specialty Pulmonology medicine.medical_treatment 030204 cardiovascular system & hematology urologic and male genital diseases Gastroenterology Malaise campylobacter jejuni 03 medical and health sciences 0302 clinical medicine Internal medicine hemic and lymphatic diseases Atypical hemolytic uremic syndrome medicine diffuse alveolar hemorrhage business.industry atypical hemolytic uremic syndrome General Engineering Diffuse alveolar hemorrhage Microangiopathic hemolytic anemia Complement deficiency Eculizumab medicine.disease female genital diseases and pregnancy complications Oncology hemolytic uremic syndrome Plasmapheresis eculizumab medicine.symptom business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Cureus |
| ISSN: | 2168-8184 |
| Popis: | Hemolytic uremic syndrome (HUS) is a constellation of microangiopathic hemolytic anemia, thrombocytopenia, and acute renal injury. HUS is subcategorized into primary or secondary HUS. Primary HUS is synonymous with atypical HUS (aHUS) and is attributed to genetic complement deficiency. Diffuse alveolar hemorrhage (DAH) is a serious condition complicating multiple systemic conditions. aHUS presenting as DAH is exceedingly rare. In this case, we present a 75-year-old male patient who presented with generalized weakness, malaise, and hemoptysis. He was found to have hemolytic anemia and thrombocytopenia, with elevated creatinine. Bronchoscopy confirmed DAH. He was started on plasmapheresis with a suboptimal response. aHUS was suspected and the patient was started on eculizumab with subsequent laboratory and clinical improvement. HUS and aHUS can present as DAH. It is very important to recognize both conditions as both are life threatening with high morbidity and mortality. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|