Nicotinamide Phosphoribosyl Transferase a Reliable Marker of Progression in Cervical Dysplasia
| Autor: | James D. Cotelingam, Rodney E. Shackelford, Junaid Ansari, Lubna Alattia, Menchu Ong, Domenico Coppola, Moiz Vora |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cancer Research Cervix Uteri Nicotinamide adenine dinucleotide Cervical intraepithelial neoplasia Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Biomarkers Tumor Medicine Humans Nicotinamide Phosphoribosyltransferase neoplasms Tissue microarray Nicotinamide business.industry General Medicine medicine.disease Uterine Cervical Dysplasia Immunohistochemistry Epithelium stomatognathic diseases 030104 developmental biology medicine.anatomical_structure Oncology chemistry Dysplasia Tissue Array Analysis 030220 oncology & carcinogenesis Cancer research Disease Progression Cytokines Female NAD+ kinase business |
| Zdroj: | Anticancer Res |
| ISSN: | 1791-7530 |
| Popis: | Background/aim Nicotinamide phosphoribosyl transferase (Nampt) catalyses the rate-limiting step of the mammalian nicotinamide adenine dinucleotide (NAD) salvage pathway. Nampt is highly expressed in several epithelial and mesenchymal neoplasms, where is promotes cell-cycle progression ans chemotherapy resistance. To our knowledge, alterations in Nampt expression have not been examined in cervical intraepithelial neoplasia (CIN) or squamous cell carcinoma (SCC). Materials and methods We performed immunohistochemical analysis for Nampt using tissue microarrays on 14 samples of benign cervical squamous epithelium and 15 CIN I, 15 CIN II, and 13 samples of CIN III. The SCCs included 5 low-grade, 67 intermediate-grade, and 81 high-grade tumors. Results Nampt levels increased with increased CIN grades were compared to benign cervical squamous epithelium. Similarly, Nampt levels increased with increasing SCC grade. Conclusion Nampt expression is a reliable marker of progression in cervical dysplasia and SCC. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|