Metformin: Mechanisms in Human Obesity and Weight Loss
| Autor: | Armen Yerevanian, Alexander A. Soukas |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Aging endocrine system diseases media_common.quotation_subject medicine.medical_treatment 030209 endocrinology & metabolism Type 2 diabetes Bioinformatics Article Management of obesity 03 medical and health sciences 0302 clinical medicine Weight loss Diabetes mellitus Weight Loss medicine Animals Humans Hypoglycemic Agents Insulin Obesity media_common 030109 nutrition & dietetics business.industry digestive oral and skin physiology nutritional and metabolic diseases Appetite General Medicine medicine.disease Metformin Gastrointestinal Microbiome Disease Models Animal Diabetes Mellitus Type 2 medicine.symptom business medicine.drug |
| Zdroj: | Curr Obes Rep |
| ISSN: | 2162-4968 |
| DOI: | 10.1007/s13679-019-00335-3 |
| Popis: | PURPOSE OF REVIEW: Metformin has multiple benefits for health beyond its antihyperglycemic properties. The purpose of this manuscript is to review the mechanisms that underlie metformin’s effects on obesity. RECENT FINDINGS: Metformin is first line therapy for type 2 diabetes. Large cohort studies have shown weight loss benefits associated with metformin therapy. Metabolic consequences were traditionally thought to underlie this effect, including reduction in hepatic gluconeogenesis and reduction in insulin production. Emerging evidence suggests that metformin-associated weight loss is due to modulation of hypothalamic appetite-regulatory centers, alteration in the gut microbiome, and reversal of consequences of aging. Metformin is also being explored in the management of obesity’s sequelae such as hepatic steatosis, obstructive sleep apnea and osteoarthritis. SUMMARY: Multiple mechanisms underlie the weight loss-inducing and health-promoting effects of metformin. Further exploration of these pathways may be important in identifying new pharmacologic targets for obesity and other aging-associated metabolic diseases. |
| Databáze: | OpenAIRE |
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