Adhesion and Proliferation of Fibroblasts on Cluster-Assembled Nanostructured Carbon Films: The Role of Surface Morphology
| Autor: | Carla Perego, D. Gualandris, Cristina Lenardi, Alessandro Podestà, S. Vinati, Paolo Piseri, Anna D’Amico, Paolo Milani, Francesca Fiorentini, G. Bongiorno, F. Vellea Sacchi, Valeria Cassina |
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| Přispěvatelé: | Lenardi, C, Perego, C, Cassina, V, Podestà, A, D'Amico, A, Gualandris, D, Vinati, S, Fiorentini, F, Bongiorno, G, Piseri, P, Vellea Sacchi, F, Milani, P |
| Rok vydání: | 2006 |
| Předmět: |
Morphology (linguistics)
Materials science Macromolecular Substances Surface Properties Cell Culture Techniques Molecular Conformation Biomedical Engineering chemistry.chemical_element Nanoparticle Bioengineering Nanotechnology Focal adhesion Extracellular matrix Mice NANOSTRUCTURED FILMS Materials Testing Cell Adhesion Animals General Materials Science Particle Size Cell adhesion Cell Proliferation SUBSTRATE TOPOGRAPHY Tissue Engineering FOCAL ADHESIONS ATOMIC FORCE MICROSCOPY Membranes Artificial General Chemistry Adhesion Fibroblasts Condensed Matter Physics Carbon Nanostructures Carbon film CELL-SUBSTRATE INTERACTIONS chemistry NIH 3T3 Cells Biophysics Crystallization |
| Zdroj: | Journal of Nanoscience and Nanotechnology. 6:3718-3730 |
| ISSN: | 1533-4880 |
| DOI: | 10.1166/jnn.2006.619 |
| Popis: | We have investigated the influence on adhesion and proliferation of NIH 3T3 fibroblasts of the surface morphology of cluster assembled carbon films deposited by Supersonic Cluster Beam Deposition. Nanostructured carbon films exhibit a multi-scale morphology, which resembles the surface structure of the extracellular matrix, and possess a high specific area, while being relatively smooth at all scales. Correlations between measured morphological parameters and adaptive cell response have been brought out. High specific area and smoothness appear to conceivably favour both the early attachment of plated cells and the long-term survival of adherent cells. Moreover, nano-structured carbon films affect the cells morphology as well as the extension and the number of the focal contacts. |
| Databáze: | OpenAIRE |
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