Transection of peripheral nerves, bridging strategies and effect evaluation
| Autor: | Albert Gramsbergen, Koen Jansen, J. IJkema-Paassen, Marcel F. Meek |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Long lasting
Biophysics Transplants Bioengineering sciatic nerve WALKING TRACK ANALYSIS Adult age RAT SCIATIC-NERVE TIBIAL-NERVE Biomaterials Peripheral Nerve Injuries Absorbable Implants Animals Humans Medicine nerve transection rat Peripheral Nerves ELECTRICAL-STIMULATION PROMOTES Tibial nerve MOTOR UNITS LATERAL GASTROCNEMIUS Environmental enrichment business.industry biodegradable nerve guide ADULT-RATS Anatomy Prognosis Spinal cord reinnervation Nerve Regeneration Peripheral Disease Models Animal Treatment Outcome medicine.anatomical_structure Mechanics of Materials Ceramics and Composites DENATURED MUSCLE-TISSUE Sciatic nerve FUNCTIONAL RECOVERY SPINAL-CORD business Reinnervation |
| Zdroj: | Biomaterials. 25(9):1583-1592 |
| ISSN: | 0142-9612 |
| DOI: | 10.1016/s0142-9612(03)00504-0 |
| Popis: | Disruption of peripheral nerves due to trauma is a frequently Occurring clinical problem. Gaps in the nerve are bridged by guiding the regenerating nerves along autologous grafts or artificial guides. This review gives an overview oil the different methods of nerve repair techniques. Conventional suturing techniques are discussed Lis well as the use of e.g. biological, synthetic, non-degradable or degradable nerve guides. Functional assessment showed that repair of a gap with a bio-degradable guide is superior to that with autologous grafts. But still, long lasting changes were observed in the Sciatic Function Index (SFI), abnormal walking patterns, disturbed Electro Myo Graphic (EMG) patterns, next to shifts in the histochemical properties of the muscles and longlasting abnormalities in neuromuscular contacts. These phenomena are explained by an at-random reinnervation. When transecting the nerve at young ages, this did not lead to enhanced recovery. Rearing rats operated at adult age in an enriched environment, also had no beneficial effect. Future research should aim at developing longer guides, possibly lined with Schwann cells, or additives, improving specific reinnervation of the former target areas. (C) 2003 Elsevier Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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