Dyspigmentation, skin physiology, and a novel approach to skin lightening
| Autor: | Christian Oresajo, Nannan Chen, Margarita Yatskayer, Amanda Dahl, Yevgeniy Krol, Zoe Diana Draelos |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Skin Lightening Preparations Skin physiology Tretinoin Dermatology Skin tone Administration Cutaneous chemistry.chemical_compound Double-Blind Method Ellagic Acid Yeasts Humans Medicine business.industry Treatment regimen Spot intensity Middle Aged Hydroquinones Drug Combinations Treatment Outcome chemistry Tolerability Patient Satisfaction Face Female Salicylic Acid business Pigmentation Disorders Salicylic acid Ellagic acid medicine.drug |
| Zdroj: | Journal of Cosmetic Dermatology. 12:247-253 |
| ISSN: | 1473-2130 |
| DOI: | 10.1111/jocd.12066 |
| Popis: | SummaryBackground Even facial pigmentation is considered a universal sign of youth and beauty in all cultures and at all ages in both men and women. The recent FDA concern about the safety of topical hydroquinone has provided the impetus for research into new pigment lightening alternatives in the cosmetic OTC market. Aim This research examined a novel hydroxyphenoxy propionic acid, ellagic acid, yeast extract, and salicylic acid formulation applied twice daily compared to the standard prescription combination of 4% hydroquinone cream and 0.025% tretinoin cream applied nightly. Method This single-center investigator-blinded 12 week study enrolled 82 subjects (7 male, 75 female) ages 25–60 years divided into 2 balanced groups of 41 subjects each with one group using a novel hydroxyphenoxy propionic acid, ellagic acid, yeast extract, and salicylic acid formulation applied twice daily compared to the standard prescription combination of 4% hydroquinone cream and 0.025% tretinoin cream applied nightly. Results Significant tolerability issues arose with the prescription combinations that were not seen with the cosmetic formulation. In terms of ability to even skin tone, decrease spot intensity, decrease spot size, and improve overall pigmentation, both products demonstrated parity. Conclusion This research demonstrated the value of cosmetic formulations as part of a treatment regimen for pigmentation issues. |
| Databáze: | OpenAIRE |
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