Circulating microRNAs are deregulated in overweight/obese children: preliminary results of the I.Family study
| Autor: | Pasquale Marena, Wolfgang Ahrens, Giuseppe Iacomino, Pasquale De Luca, Fabio Lauria, Alfonso Siani, Ilaria Stillitano, Paola Russo |
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| Jazyk: | angličtina |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Endocrinology Diabetes and Metabolism Metabolic disorders Clinical nutrition Overweight Biology Childhood obesity childhood obesity biomarker metabolic disorders circulating miRNAs 03 medical and health sciences 0302 clinical medicine Internal medicine microRNA medicine Genetics Research Biomarker medicine.disease Obesity 3. Good health Circulating MicroRNA 030104 developmental biology Endocrinology 030220 oncology & carcinogenesis Cohort Biomarker (medicine) medicine.symptom Circulating miRNAs |
| Zdroj: | Genes & nutrition 11 (2016): 1–9. doi:10.1186/s12263-016-0525-3 info:cnr-pdr/source/autori:Giuseppe Iacomino, Paola Russo, Ilaria Stillitano, Fabio Lauria, Pasquale Marena, Wolfgang Ahrens, Pasquale De Luca and Alfonso Siani/titolo:Circulating microRNAs are deregulated in overweight%2Fobese children: preliminary results of the I.Family study/doi:10.1186%2Fs12263-016-0525-3/rivista:Genes & nutrition/anno:2016/pagina_da:1/pagina_a:9/intervallo_pagine:1–9/volume:11 Genes & Nutrition Genes & nutrition, 11:7 |
| ISSN: | 1555-8932 |
| DOI: | 10.1186/s12263-016-0525-3 |
| Popis: | Background MicroRNAs (miRNAs) are small non-coding RNAs involved in the modulation of gene expression and in the control of numerous cell functions. Alterations of miRNA patterns frequently occur in cancer and metabolic disorders, including obesity. Recent studies showed remarkable stability of miRNAs in both plasma and serum making them suitable as potential circulating biomarkers for a variety of diseases and conditions. The aim of this study was to assess the profile of circulating miRNAs expressed in plasma samples of overweight or obese (OW/Ob) and normal weight (NW) prepubertal children from a European cohort (www.ifamilystudy.eu). The project, aimed to assess the determinants of eating behavior in children and adolescents of eight European countries, is built on the IDEFICS cohort (www.ideficsstudy.eu), established in 2006. Among the participants of the I.Family Italian Cohort, ten OW/Ob (age 10.7 ± 1.5 years, BMI 31.6 ± 4.3 kg/m2) and ten NW (age 10.5 ± 2.7 years, BMI 16.4 ± 1.7 kg/m2) children were selected for the study. Gene arrays were employed to differentially screen the expression of 372 miRNAs in pooled plasma samples. Deregulated miRNAs (p |
| Databáze: | OpenAIRE |
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