Frequency and Clinical Course of Residual Orbital Masses After Treatment of Orbital Rhabdomyosarcoma
| Autor: | Bita Esmaeli, J. Matthew Debnam, Gregory J. Griepentrog, Wenli Dong, Rachel K. Sobel, Joshua Ford, Erin M. Shriver |
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| Rok vydání: | 2022 |
| Předmět: |
Male
Orbital rhabdomyosarcoma medicine.medical_specialty Chemotherapy medicine.diagnostic_test business.industry medicine.medical_treatment Remission Induction Clinical course Debulking Combined Modality Therapy Response to treatment Radiation therapy Ophthalmology Rhabdomyosarcoma Biopsy Humans Orbital Neoplasms Medicine Radiology business After treatment Retrospective Studies |
| Zdroj: | American Journal of Ophthalmology. 234:28-36 |
| ISSN: | 0002-9394 |
| Popis: | PURPOSE: To evaluate the frequency and clinical course of residual orbital masses on imaging studies after multimodality treatment for orbital rhabdomyosarcoma. DESIGN: Retrospective case series METHODS: : We reviewed records of patients with primary orbital rhabdomyosarcoma who underwent chemotherapy and radiotherapy after surgical biopsy or debulking at 4 US centers during 1998-2019. Demographics, histologic subtype, tumor response 12 weeks after chemotherapy initiation and after completion of all treatment, and imaging findings were analyzed. RESULTS: Thirty-two patients met inclusion criteria. Twenty-two were male, and 30 were younger than 18 years. Histologic subtype was embryonal in 22 patients, alveolar in 8, and mixed embryonal/alveolar in 2. Median follow-up time was 46 months (range, 4.9-199 months). Two patients died. Twenty-seven patients had reliable end-of-treatment imaging findings, of whom 9 had a residual mass. Three residual masses disappeared spontaneously (by 4, 32, and 53 months), 2 remained at last contact, at 2 and 7 years of follow-up, and 3 were excised; 1 progressed and underwent an exenteration. Complete response at 12 weeks was associated with complete response at the end of treatment (p |
| Databáze: | OpenAIRE |
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