Effects of smoking on local delivery of controlled-release doxycycline as compared to scaling and root planing
| Autor: | Bradley Beiswanger, Horn Lay Wang, Valerie L. Blanco, Kevin J. Donly, Raymond Yukna, Gary Bogle, E. Brady Hancock, Charles E. Hawley, Steven Garrett, Alan M. Polson, Graham Carron, Mark I. Ryder, Lonnie Johnson, Lawrence E. Wolinsky, Philip J. Hanes, Barbara Pons, William W. Hallmon, Donald F. Adams |
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| Rok vydání: | 1999 |
| Předmět: |
Polymers
Administration Topical Polyesters Bleeding on probing Dentistry Doxycycline Hyclate law.invention Root Planing Scaling and root planing Randomized controlled trial law Periodontal Attachment Loss medicine Humans Periodontal Pocket Single-Blind Method Lactic Acid Periodontal Diseases Periodontitis Doxycycline business.industry Dental Plaque Index Smoking Middle Aged medicine.disease Anti-Bacterial Agents Clinical trial Treatment Outcome Delayed-Action Preparations Periodontics Dental Scaling medicine.symptom business Gingival Hemorrhage medicine.drug Follow-Up Studies |
| Zdroj: | Journal of clinical periodontology. 26(10) |
| ISSN: | 0303-6979 |
| Popis: | This paper examines the effects of smoking on the treatment outcomes of two nonsurgical therapies: (1) scaling and root planing alone (SRP) or (2) controlled-release of subgingivally delivered doxycycline hyclate in a polylactic acid based polymer gel. Subjects from 2 9-month multicenter studies were classified as nonsmokers (never smoked: 100 subjects), former smokers (137 subjects), and current smokers (> or = 10 cigarettes/day: 121 subjects). Clinical parameters were analyzed for treated sites with baseline probing depths > or = 5 mm and for a subset of treated sites with baseline probing depths of > or = 7 mm. Clinical parameters (plaque levels, clinical attachment levels, pocket depths, and bleeding on probing) were analyzed at baseline, 4, 6, and 9 months. In the doxycycline treated group in general, there were neither marked significant differences in clinical attachment gain nor differences in probing depth reduction among the 3 smoking groups. On the other hand, in the scaling and root planing treated group in general, there were significant differences in clinical attachment gain and pocket depth reduction, with non-smokers responding better than former smokers and current smokers at 6 and 9 months. These differences in clinical response between scaling and root planing alone versus controlled-release of locally-delivered doxycycline hyclate among these 3 smoking groups are discussed in relation to treatment implications for smokers. |
| Databáze: | OpenAIRE |
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