THE THICKNESSES OF CHOROID, MACULAR SEGMENTS, PERIPAPILLARY RETINAL NERVE FIBER LAYER, AND RETINAL VASCULAR CALIBER IN HIV-1-INFECTED PATIENTS WITHOUT INFECTIOUS RETINITIS
| Autor: | Gökhan Pekel, Osman Parca, Ebru Nevin Çetin, Selda Sayin Kutlu, Murat Kutlu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Retinal Ganglion Cells
choroidal thickness 0301 basic medicine Visual acuity Visual Acuity retinal pigment epithelium Nerve fiber layer Eye Infections Viral HIV Infections vein diameter chemistry.chemical_compound Nerve Fibers 0302 clinical medicine Macula Lutea retinal thickness clinical article adult correlational study General Medicine Middle Aged Prognosis retinal inner plexiform layer retinitis aged female spectral domain optical coherence tomography medicine.anatomical_structure retina blood vessel medicine.symptom Tomography Optical Coherence medicine.medical_specialty Adolescent retinal nerve fiber layer thickness Optic Disk Retinitis Article macular thickness Young Adult 03 medical and health sciences virus RNA male macular segments peripapillary retinal nerve fiber layer Ophthalmology medicine Humans cross-sectional study controlled study human Retina Retinal pigment epithelium business.industry human cell HIV CD4 lymphocyte count Retinal virus load Eye infection Human immunodeficiency virus 1 infection medicine.disease photoreceptor 030112 virology eye diseases Cross-Sectional Studies chemistry retinal vascular caliber HIV-1 030221 ophthalmology & optometry Choroid sense organs business choroid |
| Popis: | Purpose:To evaluate choroidal, macular, peripapillary retinal nerve fiber layer (RNFL) thicknesses and retinal vascular caliber alterations in HIV-1-infected patients without opportunistic infections.Methods:This cross-sectional study included 45 HIV-1-infected patients and 47 healthy subjects. Spectral domain optical coherence tomography was used for assessment of choroidal, macular, peripapillary RNFL thicknesses and retinal vascular caliber alterations.Results:The mean CD4 count was 426 ± 226 cells per milliliter and the mean HIV-1 RNA level was 1.8 × 105 ± 3.6 × 105 copies/mL in HIV-infected group. Central inner plexiform, superior photoreceptor, superior and nasal retinal pigment epithelium layers were thinner in HIV-infected patients compared with control subjects (P < 0.05). The differences in sectoral retinal thicknesses lost their significance after Bonferroni correction (P < 0.01). The average thickness of pericentral retina within 3 mm was thinner in the photoreceptor layer in HIV-infected patients compared with control subjects (P = 0.033). The differences in peripapillary RNFL thickness, choroidal thickness, and retinal vascular caliber were not significant between the groups. Choroidal thickness and pericentral outer plexiform were thinner, whereas peripapillary RNFL was thicker in newly diagnosed cases (16 patients) compared with patients having treatment for at least 4 months or longer (27 patients, P < 0.05, Mann-Whitney U test). HIV-1 RNA showed negative correlation with choroidal thickness (r =-0.435, P = 0.003) and positive correlation with peripapillary RNFL in central (r = 0.323, P = 0.032) and superonasal (r = 0.369, P = 0.014) sectors.Conclusion:Choroidal thickness was thinner in newly diagnosed patients compared with patients on treatment. Viral load showed negative correlation with choroidal thickness. Retinal segmental alterations occurred in HIV-infected patients compared with control subjects. © 2019 by Ophthalmic Communications Society, Inc. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|