Selective anticancer activity of the novel steroidal dihydropyridine spirooxindoles against human esophageal EC109 cells
| Autor: | Cong Wang, Xueyan Zhang, Dongxiao Yang, Kairui Zhou, Tiantian Qin, Xiaoli Shi, Leilei Li, Junfeng Huo, Yanling Zhang, Weihua Liu |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Dihydropyridines Esophageal Neoplasms Paclitaxel Drug Resistance Apoptosis Pharmacology Small Molecule Libraries 03 medical and health sciences 0302 clinical medicine Cell Line Tumor medicine Humans Caspase biology Chemistry Dihydropyridine Cell Cycle Checkpoints General Medicine Esophageal cancer medicine.disease Antineoplastic Agents Phytogenic G2 Phase Cell Cycle Checkpoints 030104 developmental biology Proto-Oncogene Proteins c-bcl-2 Cell culture 030220 oncology & carcinogenesis Carcinoma Squamous Cell biology.protein Reactive Oxygen Species medicine.drug |
| Zdroj: | Biomedicine & Pharmacotherapy. 96:1186-1192 |
| ISSN: | 0753-3322 |
| DOI: | 10.1016/j.biopha.2017.11.100 |
| Popis: | A series of small-molecule compounds built on steroidal dihydropyridine spirooxindoles has been reported previously. In this study, the compound 5l showed strong anti-cancer activity, especially in the esophageal cancer. Three esophageal squamous cell lines and paclitaxel-resistant cell line were investigated. The results demonstrated that compound 5l was most efficient in the EC109 cells, induced cell apoptosis through elevation of cellular ROS levels, caused G2/M phase arrest and mitochondrial dysfunction. Further study confirmed that the mechanism of 5l in esophageal cancer treatment was related to the Bcl-2 family and caspase receptor-mediated apoptotic pathway. |
| Databáze: | OpenAIRE |
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