Cerebellin1 is a novel orexigenic peptide
| Autor: | Daniel Campbell, E. M. Leavy, Kylie Beale, Waljit S. Dhillo, S.R. Bloom, Debabrata Roy, A. Bataveljic, N. A. Patel, Gavin A. Bewick, James Gardiner, Michael Patterson, M. A. Ghatei, Charlotte K. Boughton |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism media_common.quotation_subject Hypothalamus Neuropeptide Nerve Tissue Proteins 03 medical and health sciences Eating 0302 clinical medicine Endocrinology Thyroid-stimulating hormone Internal medicine Orexigenic Appetite Depressants Internal Medicine medicine Animals Protein Precursors 030304 developmental biology media_common Injections Intraventricular 2. Zero hunger 0303 health sciences Adrenal gland business.industry Appetite Regulation digestive oral and skin physiology Appetite Fasting Neuropeptide Y receptor Rats medicine.anatomical_structure Ventromedial nucleus of the hypothalamus business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Diabetes, Obesity and Metabolism; Vol 12 |
| ISSN: | 1463-1326 |
| Popis: | Aim: Cerebellin1 (Cbln1) is highly expressed in the hypothalamus, a region of the brain involved in appetite regulation. However, the effects of Cbn1 on food intake are not known. The present study aimed to investigate the effect of Cbln1 on appetite regulation in rats. Methods: We determined the effect of (i) intracerebroventricular (ICV) injection of Cbln1 on food intake, behaviour and plasma pituitary hormone levels in male Wistar rats; (ii) Cbln1 on the release of hypothalamic neuropeptides known to modulate food intake from hypothalamic explants and (iii) fasting on hypothalamic Cbln1 mRNA expression. Results: (i) ICV administration of Cbln1 significantly increased food intake in rats and caused no adverse behaviours. ICV administration of Cbln1 significantly reduced plasma thyroid stimulating hormone (TSH) levels 10 min postinjection in rats. (ii) Cbln1 significantly increased the release of neuropeptide Y (NPY) from hypothalamic explants. (iii) Cbln1 mRNA expression levels were increased in the ventromedial nucleus of the hypothalamus in fasted rats. Conclusions: These data suggest that Cbln1 is a novel orexigenic peptide, which may mediate its effects via hypothalamic NPY. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text