Variation and Interdependencies of Human Milk Macronutrients, Fatty Acids, Adiponectin, Insulin, and IGF-II in the European PreventCD Cohort
| Autor: | Katharina J. Werkstetter, M. L. Mearin, Franca F. Kirchberg, Christian Hellmuth, Gemma Castillejo, Maria Grunewald, Sabine L. Vriezinga, María Roca, Renata Auricchio, Isabel Polanco, Ilma Rita Korponay-Szabó, Hans Demmelmair, Berthold Koletzko |
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| Přispěvatelé: | Grunewald, Maria, Hellmuth, Christian, Kirchberg, Franca F, Mearin, Maria Luisa, Auricchio, Renata, Castillejo, Gemma, Korponay-Szabo, Ilma R, Polanco, Isabel, Roca, Maria, Vriezinga, Sabine L, Werkstetter, Katharina, Koletzko, Berthold, Demmelmair, Hans |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Time Factors country medicine.medical_treatment Breastfeeding Palmitic acid Cohort Studies chemistry.chemical_compound 0302 clinical medicine Lactation fat Insulin 2. Zero hunger chemistry.chemical_classification education.field_of_study Nutrition and Dietetics Postpartum Period human milk Milk Proteins 3. Good health Europe medicine.anatomical_structure Female Adiponectin lcsh:Nutrition. Foods and food supply Polyunsaturated fatty acid Human Adult medicine.medical_specialty duration of lactation Population hormone 030209 endocrinology & metabolism lcsh:TX341-641 Biology fatty acids Article Milk Protein 03 medical and health sciences Insulin-Like Growth Factor II Internal medicine Fatty Acids Omega-6 medicine Humans education 030109 nutrition & dietetics hormones Milk Human Nutrients Endocrinology chemistry carbohydrate fatty acid Cohort Studie carbohydrate celiac disease country duration of lactation fat fatty acids hormones human milk celiac disease Food Science Hormone Nutrient |
| Zdroj: | Nutrients, Vol 11, Iss 9, p 2034 (2019) Nutrients r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe instname Volume 11 Issue 9 |
| ISSN: | 2072-6643 |
| Popis: | Human milk composition is variable. The identification of influencing factors and interdependencies of components may help to understand the physiology of lactation. In this study, we analyzed linear trends in human milk composition over time, the variation across different European countries and the influence of maternal celiac disease. Within a multicenter European study exploring potential prevention of celiac disease in a high-risk population (PreventCD), 569 human milk samples were donated by women from five European countries between 16 and 163 days postpartum. Some 202 mothers provided two samples at different time points. Protein, carbohydrates, fat and fatty acids, insulin, adiponectin, and insulin-like growth factor II (IGF-II) were analyzed. Milk protein and n-6 long chain polyunsaturated fatty acids decreased during the first three months of lactation. Fatty acid composition was significantly influenced by the country of residence. IGF-II and adiponectin concentrations correlated with protein content (r = 0.24 and r = 0.35), and IGF-II also correlated with fat content (r = 0.36), suggesting a possible regulatory role of IGF in milk macronutrient synthesis. Regarding the impact of celiac disease, only the level in palmitic acid was influenced by this disease, suggesting that breastfeeding by celiac disease mothers should not be discouraged. |
| Databáze: | OpenAIRE |
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