Asymptomatic hyperuricaemia and coronary artery disease
| Autor: | Jorge Eduardo Hernández-del Río, Óscar Sergio Lomelí-Sánchez, Silvia Esmeralda Pérez-Topete, Verónica González-Díaz, Christian González-Padilla, Ramón Miguel Esturau-Santaló, Tomás Miranda-Aquino, Sergio Gutierrez-Ureña |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
030203 arthritis & rheumatology
medicine.medical_specialty business.industry nutritional and metabolic diseases Arthritis General Medicine Disease 030204 cardiovascular system & hematology urologic and male genital diseases medicine.disease Asymptomatic Gout Coronary artery disease 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry Internal medicine medicine Uric acid Observational study medicine.symptom business Kidney disease |
| Zdroj: | Reumatología Clínica (English Edition). 17:263-267 |
| ISSN: | 2173-5743 |
| Popis: | Background Uric acid has been related to a tendency to precipitate to form crystals, presenting asymptomatically, until the formation of arthritis, tophi or renal lithiasis. Previously, the presence of asymptomatic hyperuricaemia has been associated with the presence of cardiovascular disease. Objectives To determine the association of complex coronary artery disease in patients with asymptomatic hyperuricaemia. Material and methods An observational retrospective, transversal, unicentric study was conducted in a tertiary hospital in Mexico, in the period from June 2017 to March 2019. All patients admitted for coronary angiography were included; patients with gout, use of diuretics and chronic kidney disease were excluded. Results During the study period, a total of 300 patients were collected, of which 40% presented hyperuricaemia. The patients with hyperuricaemia were older (59 vs. 63, P = .002). The group of patients with asymptomatic hyperuricaemia had a higher proportion of complex coronary lesions (64 vs. 35%, P ≤ .0001) as well as a higher SYNTAX I score (27 vs. 17, P ≤ .001). There was a higher probability of presenting complex coronary lesions in this group of patients (OR 3.4, P ≤ .0001). In addition, in the group division of uric acid levels, it was related to the presence of complex coronary lesions (Q1 = .5, P = .06), (Q2 = 2, P = .01) and (Q3 = 3, P ≤ .0001). Conclusion Asymptomatic hyperuricaemia has a higher prevalence and association of presenting complex coronary lesions. |
| Databáze: | OpenAIRE |
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