TNFR-1 on tumor cells contributes to the sensitivity of fibrosarcoma to chemotherapy
Autor: | Lijie Rong, Zhihai Qin, Xiaopu Zhao, Xiao Li, Xiaoman Liu, Jingjing Deng |
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Rok vydání: | 2013 |
Předmět: |
Melphalan
Vascular Endothelial Growth Factor A medicine.medical_treatment Fibrosarcoma Down-Regulation Biology Biochemistry chemistry.chemical_compound Mice Downregulation and upregulation Drug Discovery medicine Animals Humans Molecular Targeted Therapy Chemotherapy hemic and immune systems Cell Biology medicine.disease biological factors Vascular endothelial growth factor Gene Expression Regulation Neoplastic Vascular endothelial growth factor A chemistry Receptors Tumor Necrosis Factor Type I Immunology Cancer research Tumor necrosis factor alpha Stem cell biological phenomena cell phenomena and immunity Biotechnology medicine.drug Signal Transduction Research Article |
Zdroj: | Proteincell. 4(5) |
ISSN: | 1674-8018 |
Popis: | Impaired tumor necrosis factor receptor-1 (TNFR-1) signaling has been found in some malignant tumors with poor prognosis. However, the exact role of TNFR-1 signaling in fibrosarcoma remains unclear. Here, we explored the question by comparing the growth of TNFR-1 deficient (Tnfr1 (-)) and TNFR-1 competent (Tnfr1 (+)) fibrosarcoma FB61 cells (FB61-m and FB61-R1) in mice. TNFR-1 expression on fibrosarcoma cells delayed their growth in vivo but not in vitro. Moreover, reduced FB61-R1 tumor growth was also obtained in TNFR-1 knockout mice. The mechanism relies mainly on the TNFR-1-mediated downregulation of vascular endothelial growth factor (VEGF) production by tumor cells. Importantly, treatment of FB61-m tumors with melphalan resulted in a short delay of tumor growth, followed by a quick remission. However, when FB61-R1 tumors were treated with melphalan, tumor growth was similarly delayed at first and then completely rejected. Our results reveal evidence for TNFR-1 on tumor cells as a prerequisite in chemotherapy for fibrosarcoma, and provide novel insight into the therapeutic approach against some types of tumors using TNFR-1 angonist. |
Databáze: | OpenAIRE |
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