Dietary Ziziphus jujuba Fruit Influence on Aberrant Crypt Formation and Blood Cells in Colitis-Associated Colorectal Cancer Mice
Autor: | Ming Yie Liu, Wang Hung Wu, Chung Teng Liu, Se Ping Chien, Srinivasan Periasamy |
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Rok vydání: | 2015 |
Předmět: |
Male
Cancer Research medicine.medical_specialty Carcinogenesis Colon Epidemiology Colorectal cancer Azoxymethane Adenocarcinoma medicine.disease_cause Chemoprevention Leukocyte Count Mice chemistry.chemical_compound Aberrant Crypt Foci Internal medicine Leukocytes medicine Animals Colitis Hyperplasia business.industry Dextran Sulfate Public Health Environmental and Occupational Health Cancer Ziziphus medicine.disease digestive system diseases Diet Mice Inbred C57BL Endocrinology Oncology chemistry Dysplasia Dietary Supplements Immunology Disease Progression Plant Preparations Colorectal Neoplasms business Aberrant crypt foci |
Zdroj: | Asian Pacific Journal of Cancer Prevention. 16:7561-7566 |
ISSN: | 1513-7368 |
Popis: | Ziziphus jujuba (ZJ) fruit is rich in bioactive functional components such as polysaccharides, triterpenoid acid, flavonoids and oleamide. It has been commonly used in the treatment of various diseases including diabetes, digestive disorders, diarrhea, skin infections, liver and urinary complaints. However, dietary effects with regard to chemoprevention of colon cancer have not been studied. The present study was performed to evaluate the protective effects of dietary ZJ against colitis-associated colon carcinogenesis in azoxymethane (AOM)-dextran sodium sulphate (DSS)-treated mice. AOM was injected (10 mg/kg b.wt., i.p.) and three cycles of 2% DSS in drinking water for 7 days with 14 days of normal drinking water in-between were administered to induce colitis-associated colon cancer. ZJ fruit was supplemented into feed at levels of 5 and 10%. Dietary ZJ significantly attenuated aberrant crypt foci (ACF) formation and also decreased the progression of hyperplasia to dysplasia. In addition, it significantly reduced circulating white blood cells, lymphocytes, neutrophils, monocytes, eosinophils, basophils and platelets compared to colon cancer mice. We conclude that ZJ supplementation may delay the progression of colon cancer from hyperplasia to dysplasia and ultimately adenocarcinoma and cancer. In addition, it decreased circulating tumor-related leukocytes, main regulators of cancer inflammation. Dietary consumption of ZJ fruit attenuated the formation of ACF and delayed the progression of colon cancer. |
Databáze: | OpenAIRE |
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