Neutralizing Monoclonal Antibody to Periostin Inhibits Ovarian Tumor Growth and Metastasis
| Autor: | Dennis J. Slamon, Lillian Ramos, Judith C. Gasson, David D. Chang, Beth Y. Karlan, Min Zhu, Romaine E. Saxton |
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| Rok vydání: | 2011 |
| Předmět: |
Cancer Research
medicine.drug_class Antineoplastic Agents Apoptosis Mice SCID Periostin Biology Monoclonal antibody Metastasis Extracellular matrix Mice Ovarian tumor chemistry.chemical_compound Cell Movement In vivo Cell Line Tumor medicine Animals Humans Neoplasm Metastasis Cell Proliferation Ovarian Neoplasms Antibodies Monoclonal medicine.disease Antibodies Neutralizing Xenograft Model Antitumor Assays Gene Expression Regulation Neoplastic Oncology chemistry Cell culture Immunology Cancer research Female Growth inhibition Cell Adhesion Molecules |
| Zdroj: | Molecular Cancer Therapeutics. 10:1500-1508 |
| ISSN: | 1538-8514 1535-7163 |
| DOI: | 10.1158/1535-7163.mct-11-0046 |
| Popis: | Periostin, an extracellular matrix protein, is reported to be overexpressed in a variety of human cancers and its functions seem to be linked to tumor metastasis. Our previous results show that engineered periostin overexpression promotes ovarian tumor growth and dissemination in vivo. In this study, we developed a neutra-lizing monoclonal antibody to periostin, named MZ-1, and investigated its effects on human ovarian tumor growth and metastasis. Our in vivo studies showed significant growth inhibition by MZ-1 on both subcutaneous and intraperitoneal (i.p.) tumors derived from the periostin-expressing ovarian cancer cell line A2780. In addition, MZ-1 treatment led to a reduction of the metastatic potential of these A2780 i.p. tumors. The in vivo antitumor effects of MZ-1 were linked to its specific inhibition of anchorage-independent growth and survival of periostin-expressing cells, as well as its neutralizing effects on periostin-induced cancer cell migration and invasion. The data suggest that blocking periostin expression may be a novel approach for treating the subset of invasive ovarian tumors that overexpress periostin protein. Mol Cancer Ther; 10(8); 1500–8. ©2011 AACR. |
| Databáze: | OpenAIRE |
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