Advanced glycation inhibition and protection against endothelial dysfunction induced by coumarins and procyanidins from Mammea neurophylla
| Autor: | Gilbertine Rakolomalala, Séverine Derbré, Denis Séraphin, Marc Litaudon, Pierre Tonnerre, Patricia Blanchard, Charlotte Gény, Caroline Rouger, Joseph Iharinjaka Randriamboavonjy, Bach Tai Dang, Gervaise Loirand, Pascal Richomme, Béatrice Charreau, Pierre Pacaud |
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| Přispěvatelé: | Institut de Chimie des Substances Naturelles (ICSN), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Immunointervention dans les allo et xénotransplantations, Université de Nantes (UN)-IFR26-Institut National de la Santé et de la Recherche Médicale (INSERM)-ITUN, Physiopathologie et pharmacologie cellulaires et moléculaires, Université de Nantes (UN)-IFR26-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut du thorax, Substances d'Origine Naturelle et Analogues Structuraux (SONAS), Université d'Angers (UA), Molécules bioactives, conception, isolement et synthèse (MBCIS), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2014 |
| Předmět: |
Glycation End Products
Advanced Male Cell Survival Stereochemistry Xanthones Friedelin Pharmacology Catechin Terpene chemistry.chemical_compound Coumarins Glycation Betulinic acid Drug Discovery Animals Biflavonoids Proanthocyanidins Rats Wistar Betulinic Acid Molecular Structure biology [CHIM.ORGA]Chemical Sciences/Organic chemistry Plant Extracts Endothelial Cells Mammea Clusiaceae General Medicine biology.organism_classification Calophyllaceae Antineoplastic Agents Phytogenic Triterpenes Rats 3. Good health Plant Leaves chemistry Phytochemical Fruit Plant Bark Pentacyclic Triterpenes |
| Zdroj: | Fitoterapia Fitoterapia, Elsevier, 2014, 96, pp.65-75. ⟨10.1016/j.fitote.2014.04.005⟩ |
| ISSN: | 0367-326X 1873-6971 |
| Popis: | International audience; Advanced glycation end-products (AGEs) are associated with many pathogenic disorders such as pathogenesis of diabetes or endothelial dysfunction leading to cardiovascular events. Therefore, the identification of new anti-AGE molecules or extracts aims at preventing such pathologies. Many Clusiaceae and Calophyllaceae species are used in traditional medicines to treat arterial hypertension as well as diabetes. Focusing on these plant families, an anti-AGE plant screening allowed us to select Mammea neurophylla for further phytochemical and biological studies. Indeed, both DCM and MeOH stem bark extracts demonstrated in vitro their ability to prevent inflammation in endothelial cells and to reduce vasoconstriction. A bioguided fractionation of these extracts allowed us to point out 4-phenyl- and 4-(1-acetoxypropyl)coumarins and procyanidins as potent inhibitors of AGE formation, potentially preventing endothelial dysfunction. The fractionation steps also led to the isolation of two new compounds, namely neurophyllols A and B from the DCM bark extract together with thirteen known mammea A and E coumarins (mammea A/AA, mammea A/AB, mammea A/BA, mammea A/BB, mammea A/AA cycloD, mammea A/AB cycloD, disparinol B, mammea A/AB cycloE, ochrocarpin A, mammea A/AA cycloF, mammea A/AB cycloF, mammea E/BA, mammea E/BB) as well as δ-tocotrienol, xanthones (1-hydroxy-7-methoxyxanthone, 2-hydroxyxanthone) and triterpenes (friedelin and betulinic acid). During this study, R,S-asperphenamate, previously described from fungal origin was also purified. |
| Databáze: | OpenAIRE |
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