Effect of Strontium Chloride on Experimental Bladder Inflammation in Rat
| Autor: | Esat Korgali, E.Y. Gultekin, Gokce Dundar, Kübra Açıkalın Coşkun, Gökhan Gökçe, Semih Ayan, Melih Akyol, Yusuf Tutar |
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| Přispěvatelé: | Korgali, E., Department of Urology, Urology Clinic, Cumhuriyet University, Sivas, 58140, Turkey -- Dundar, G., Department of Urology, Urology Clinic, Cumhuriyet University, Sivas, 58140, Turkey -- Coskun, K.A., Department of Bioengineering, Natural Sciences and Engineering Faculty, Gaziosmanpasa University, Tokat, 60250, Turkey -- Akyol, M., Department OfDermatology, Medical Faculty, Cumhuriyet University, Sivas, 58140, Turkey -- Tutar, Y., Department of Biochemistry, Pharmacy Faculty, Cumhuriyet University, Sivas, 58140, Turkey -- Ayan, S., Department of Urology, Urology Clinic, Cumhuriyet University, Sivas, 58140, Turkey -- Gokce, G., Department of Urology, Urology Clinic, Cumhuriyet University, Sivas, 58140, Turkey -- Gultekin, E.Y., Department of Urology, Urology Clinic, Cumhuriyet University, Sivas, 58140, Turkey, Tokat Gaziosmanpaşa Üniversitesi |
| Rok vydání: | 2014 |
| Předmět: |
inorganic chemicals
musculoskeletal diseases Strontium medicine.medical_specialty Article Subject business.industry Strontium chloride Urology Interstitial cystitis chemistry.chemical_element Urine medicine.disease medicine.disease_cause Pathophysiology chemistry.chemical_compound chemistry Immunology medicine Histopathology Irritation business Histamine Research Article |
| Zdroj: | International Scholarly Research Notices |
| ISSN: | 2356-7872 |
| DOI: | 10.1155/2014/369292 |
| Popis: | Hindawi Limited Introduction. Strontium salts are anti-irritants for chemically induced sensory irritation. Interstitial cystitis is a painful disease without definitive therapy. The aim of the study was to determine the effect of strontium in bladder with experimental interstitial cystitis model. Material and Methods. Rats' bladders in control group were instilled with NaCl. Second group was instilled with E. coli LPS. Third group was instilled with strontium. Fourth group was initially instilled with strontiumand then LPS. Fifth group was instilled with LPS initially and then strontium. Urine of rats was collected at the beginning and end of the study. Results. Histamine and TNF-P changes were statistically significant in the second group but were not significant in the third group.When we compared the histamine levels of second via fourth and fifth groups the changes were statistically not significant.When we compared the TNF- P levels of second via fourth and fifth groups the changes were statistically significant. Conclusions. In our model, strontiumdid not make any significant changes in histopathology or histamine levels; however, it significantly reduced the levels of TNF-P. Given the role of TNF-P in the physiopathology of interstitial cystitis, these results suggested that further studies are required to evaluate the potential use of strontium in the management of interstitial cystitis. Korgali, E.; Department of Urology, Urology Clinic, Cumhuriyet UniversityTurkey; email: estkorgali@hotmail.com |
| Databáze: | OpenAIRE |
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