Myelopoiesis and erythropoiesis of bone marrow cells cultured in vitro in patients recovered from aplastic anaemia
| Autor: | R. Ruvidić, A. Mijović, Nevenka Stojanovic, L. Biljanović‐Paunović, Gordana Jovčić, V. Pavlović‐Kentera |
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| Rok vydání: | 1985 |
| Předmět: |
Adult
Male Bone Marrow Cells Colony-Forming Units Assay Colony-Stimulating Factors Medicine Humans Erythropoiesis Aplastic anemia Progenitor cell Erythropoietin Cells Cultured business.industry Anemia Aplastic Hematology Middle Aged medicine.disease Colony-stimulating factor Hematopoietic Stem Cells Hematopoiesis medicine.anatomical_structure Immunology Cancer research Androgens Female Myelopoiesis Bone marrow Stem cell business medicine.drug |
| Zdroj: | Scandinavian journal of haematology. 35(4) |
| ISSN: | 0036-553X |
| Popis: | Methylcellulose culture assay was used to detect committed haemopoietic stem cells, CFU-C and CFU-E, in aplastic anaemia patients with autologous haemopoietic reconstitution. Severe diminution of CFU-C was found in all the patients studied and the absence of a dose-response to colony stimulating factor (CSF) was demonstrated. A reduced number of CFU-E and lower erythropoietin (Ep) sensitivity of those progenitors was detected as well. Autologous serum added to the bone marrow cultures of these patients enhanced the growth of CFU-C but inhibited CFU-E growth. According to the results presented, some residual damage at the stem cell level is suggested. |
| Databáze: | OpenAIRE |
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