Co-Expression of Nogo-A in Dopaminergic Neurons of the Human Substantia Nigra Pars Compacta Is Reduced in Parkinson���s Disease
| Autor: | Stefanie Seiler, Lukas Andereggen, Hans Rudolf Widmer, Ekkehard Hewer, Gian-Carlo Eyer, Stefano Di Santo |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Aging Parkinson's disease Tyrosine 3-Monooxygenase QH301-705.5 Nogo Proteins Cell Count Substantia nigra 610 Medicine & health Disease Normal aging Biology Article Age Factors Aged Aged 80 and over Aging/metabolism Dopaminergic Neurons/metabolism Humans Nogo Proteins/metabolism Parkinson Disease/metabolism Substantia Nigra/metabolism Tyrosine 3-Monooxygenase/metabolism Nogo-A Parkinson’s disease human immunofluorescence substantia nigra pars compacta tyrosine hydroxylase mental disorders medicine Biology (General) Tyrosine hydroxylase Pars compacta Dopaminergic Neurons Dopaminergic Neurodegeneration Parkinson Disease General Medicine medicine.disease nervous system diseases Substantia Nigra nervous system 570 Life sciences biology Neuroscience |
| Zdroj: | Eyer, Gian-Carlo; Di Santo, Stefano; Hewer, Ekkehard; Andereggen, Lukas; Seiler, Stefanie; Widmer, Hans Rudolf (2021). Co-Expression of Nogo-A in Dopaminergic Neurons of the Human Substantia Nigra Pars Compacta Is Reduced in Parkinson’s Disease. Cells, 10(12) MDPI 10.3390/cells10123368 Cells, Vol 10, Iss 3368, p 3368 (2021) Cells Cells; Volume 10; Issue 12; Pages: 3368 Cells, vol. 10, no. 12, pp. 3368 |
| DOI: | 10.48350/162703 |
| Popis: | Parkinson’s disease is mainly characterized by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta. Together with the small number, the high vulnerability of the dopaminergic neurons is a major pathogenic culprit of Parkinson’s disease. Our previous findings of a higher survival of dopaminergic neurons in the substantia nigra co-expressing Nogo-A in an animal model of Parkinson’s disease suggested that Nogo-A may be associated with dopaminergic neurons resilience against Parkinson’s disease neurodegeneration. In the present study, we have addressed the expression of Nogo-A in the dopaminergic neurons in the substantia nigra in postmortem specimens of diseased and non-diseased subjects of different ages. For this purpose, in a collaborative effort we developed a tissue micro array (TMA) that allows for simultaneous staining of many samples in a single run. Interestingly, and in contrast to the observations gathered during normal aging and in the animal model of Parkinson’s disease, increasing age was significantly associated with a lower co-expression of Nogo-A in nigral dopaminergic neurons of patients with Parkinson’s disease. In sum, while Nogo-A expression in dopaminergic neurons is higher with increasing age, the opposite is the case in Parkinson’s disease. These observations suggest that Nogo-A might play a substantial role in the vulnerability of dopaminergic neurons in Parkinson’s disease. |
| Databáze: | OpenAIRE |
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