Enzyme‐Engineered Conjugated Polymer Nanoplatform for Activatable Companion Diagnostics and Multistage Augmented Synergistic Therapy

Autor:	Jiayingzi Wu, Yafei Zhang, Kejia Jiang, Xiaoyu Wang, Nicholas Thomas Blum, Jing Zhang, Shanshan Jiang, Jing Lin, Peng Huang
Rok vydání:	2022
Předmět:	Glucose Oxidase Photothermal Therapy Polymers Mechanics of Materials Cell Line Tumor Neoplasms Mechanical Engineering Tumor Microenvironment Humans Nanoparticles General Materials Science
Zdroj:	Advanced Materials. 34:2200062
ISSN:	1521-4095 0935-9648
DOI:	10.1002/adma.202200062
Popis:	Companion diagnostics (CDx) provides critical information for precision medicine. However, current CDx is mostly limited to in vitro tests, which cannot accurately evaluate the disease progression and treatment response in real time. To overcome this challenge, herein a glucose oxidase (GOx)-engineered conjugated polymer (polyaniline, PANI) nanoplatform (denoted as PANITG) is reported for activatable imaging-based CDx and multistage augmented photothermal/starvation synergistic therapy. PANITG comprises a pH-activatable conjugated polymer as a photothermal convertor and photoacoustic (PA) emitter, a GOx as a cancer starvation inducer as well as a H
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1635787bd21b37a71d99cde78197314 https://doi.org/10.1002/adma.202200062 Zobrazit plný text záznamu Plný text