Long-term prognosis of rheumatic fever patients receiving regular intramuscular benzathine penicillin
Autor: | Bernard Boxerbaum, Jerome Liebman, Dorothy G. Tompkins |
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Rok vydání: | 1972 |
Předmět: |
Adult
Male medicine.medical_specialty Time Factors Adolescent QRS complex Physiology (medical) Internal medicine medicine Endocarditis Humans Mitral Valve Stenosis cardiovascular diseases Child Benzathine penicillin business.industry Rheumatic Heart Disease Mitral Valve Insufficiency medicine.disease Prognosis Surgery Stenosis Endocarditis Subacute Bacterial Regurgitation (digestion) cardiovascular system Acute mitral regurgitation Cardiology Penicillin G Benzathine Rheumatic fever Female Penicillin prophylaxis medicine.symptom Rheumatic Fever Cardiology and Cardiovascular Medicine business Follow-Up Studies Heart Auscultation |
Zdroj: | Circulation. 45(3) |
ISSN: | 0009-7322 |
Popis: | The prognosis for 115 rheumatic fever patients subsequently receiving regular intramuscular penicillin prophylaxis for at least 5 years was studied. Average follow-up was 9.3 years, and 57 patients were followed for 10 years or longer. Of the 79 patients with acute mitral regurgitation, 70% lost their murmur from 4 days to 8.5 years after it was first heard. This is in contrast to those with acute aortic regurgitation which persisted in 73%. No patient developed mitral or aortic stenosis: this suggests that regular prophylaxis may prevent the development of stenosis. Congestive failure, cardiomegaly, and arrhythmia correlated closely with persistence of murmurs, but increased P-R interval, acute QRS or T-voltage variation or both, and ST-T abnormalities did not. |
Databáze: | OpenAIRE |
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