Brain fMRI during orientation selective epidural spinal cord stimulation
| Autor: | Jun Ma, Clark C. Chen, Igor Lavrov, Shalom Michaeli, Lin Wu, Sheng Sang, Fabrizio Esposito, Lauri J. Lehto, Antonietta Canna, Olli Gröhn, Hanne Laakso, Silvia Mangia, Pavel Filip, Yuan Zhang |
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| Přispěvatelé: | Canna, Antonietta, Lehto, Lauri J., Wu, Lin, Sang, Sheng, Laakso, Hanne, Ma, Jun, Filip, Pavel, Zhang, Yuan, Gröhn, Olli, Esposito, Fabrizio, Chen, Clark C., Lavrov, Igor, Michaeli, Shalom, Mangia, Silvia |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Epidural Space
Male 0301 basic medicine Deep brain stimulation Science medicine.medical_treatment Sensory system Stimulation Neural circuits Article Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Biological neural network Animals Medicine Spinal cord injury Spinal Cord Injuries Spinal Cord Stimulation Multidisciplinary medicine.diagnostic_test business.industry Chronic pain Magnetic resonance imaging medicine.disease Spinal cord Magnetic Resonance Imaging Electrodes Implanted Rats 030104 developmental biology medicine.anatomical_structure Preclinical research business Biomedical engineering Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021) Scientific Reports |
| Popis: | Epidural spinal cord stimulation (ESCS) is widely used for chronic pain treatment, and is also a promising tool for restoring motor function after spinal cord injury. Despite significant positive impact of ESCS, currently available protocols provide limited specificity and efficiency partially due to the limited number of contacts of the leads and to the limited flexibility to vary the spatial distribution of the stimulation field in respect to the spinal cord. Recently, we introduced Orientation Selective (OS) stimulation strategies for deep brain stimulation, and demonstrated their selectivity in rats using functional MRI (fMRI). The method achieves orientation selectivity by controlling the main direction of the electric field gradients using individually driven channels. Here, we introduced a similar OS approach for ESCS, and demonstrated orientation dependent brain activations as detected by brain fMRI. The fMRI activation patterns during spinal cord stimulation demonstrated the complexity of brain networks stimulated by OS-ESCS paradigms, involving brain areas responsible for the transmission of the motor and sensory information. The OS approach may allow targeting ESCS to spinal fibers of different orientations, ultimately making stimulation less dependent on the precision of the electrode implantation. |
| Databáze: | OpenAIRE |
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