Sildenafil increases cerebrovascular reactivity: A transcranial Doppler study

Autor:	Giorgia Leone, F. Ferrante, Fabrizio Sallustio, E. Spera, Barbara Rizzato, Giorgio Bernardi, M. Scarfini, Marina Diomedi
Jazyk:	angličtina
Rok vydání:	2005
Předmět:	Male double blind procedure Time Factors Ultrasonography Doppler Transcranial Phosphodiesterase Inhibitors sildenafil brain blood vessel pulse wave hemodynamics Piperazines law.invention Brain Ischemia Placebos chemistry.chemical_compound breath holding Randomized controlled trial law migraine Sulfones Ultrasonography clinical article article Doppler clinical trial Middle Aged Vasodilation blood flow velocity priority journal Anesthesia Cerebrovascular Circulation cardiovascular system Settore MED/26 - Neurologia Drug headache Sildenafil erectile dysfunction Migraine Disorders blood vessel reactivity Transcranial Sildenafil Citrate Dose-Response Relationship Cerebrovascular reactivity Double-Blind Method medicine drug mechanism Humans controlled study human Aged Dose-Response Relationship Drug controlled clinical trial business.industry Endothelial Cells Cerebral Arteries medicine.disease respiratory tract diseases Transcranial Doppler Migraine chemistry Cerebral hemodynamics Purines randomized controlled trial placebo Doppler echography Neurology (clinical) business male
Popis:	The authors performed a double-blind, placebo-controlled study in 28 patients to evaluate the effects of sildenafil on cerebral hemodynamics. A significant improvement of cerebrovascular reactivity, without any modification of other variables, was recorded 1 hour after the administration of 50 mg sildenafil. Further investigations are needed to evaluate whether cerebrovascular reactivity improvement could contribute to triggering sildenafil-induced migraine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f15dea5d5be829a1c8ea50c26ca06122 http://hdl.handle.net/2108/32832 Zobrazit plný text záznamu