Lectin rich horsegram protein and myricetin activates insulin signaling – A study targeting PTP1β
| Autor: | Sridevi Annapurna Singh, Ramaprasad Ravichandra Talahalli, Nanjaiah Lalitha, Bettadahalli Sadashivaiah |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
animal structures Medicine (miscellaneous) medicine.disease_cause Horsegram protein Proinflammatory cytokine chemistry.chemical_compound Insulin resistance stomatognathic system Internal medicine medicine TX341-641 Receptor Nutrition and Dietetics biology Nutrition. Foods and food supply Myricetin myr social sciences Insulin sensitivity medicine.disease Streptozotocin body regions Insulin receptor Protein tyrosine phosphatase 1β Endocrinology chemistry biology.protein Fasting blood glucose level Oxidative stress Food Science medicine.drug |
| Zdroj: | Journal of Functional Foods, Vol 67, Iss, Pp 103845-(2020) |
| ISSN: | 1756-4646 |
| DOI: | 10.1016/j.jff.2020.103845 |
| Popis: | Horsegram, a rich source of myricetin (Myr), exhibits an anti-hyperglycemic effect. We examined the individual and combinational effect of Myr and horsegram protein (HP) on protein tyrosine phosphatase 1β (PTP1β), and its effect on insulin signaling in high-fat-diet (HFD) and a single dose of streptozotocin (STZ) induced diabetic rat model. Myr, HP, and their combination, Myr + HP, were orally administered to diabetic animals for four weeks. Myr, HP, and Myr + HP were effective in reducing elevated blood glucose, HbA1c, fasting insulin, insulin resistance, oxidative stress markers, and proinflammatory cytokines. Myr ameliorated dyslipidemia and significantly reduced PTP1β activity; HP and Myr + HP were not as effective, although they suppressed the expression of PTP1β. Myr and HP treated groups had elevated levels of the phospho-insulin receptor (pIR), phospho-insulin receptor substrate1 (pIRS1), and phospho-Akt (pAkt), whereas, Myr + HP was not effective. Though myricetin and horsegram proteins ameliorate diabetic conditions, dietary intake of their combination reduced individual efficiency. |
| Databáze: | OpenAIRE |
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