Vitamin D in Older Adults: The Need to Specify Standard Values with Respect to Cognition
| Autor: | Olivier Beauchet, Cédric Annweiler |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
cognition
Aging medicine.medical_specialty Neuroactive steroid Cognitive Neuroscience Central nervous system vitamin D Calcitriol receptor lcsh:RC321-571 Bone remodeling Internal medicine Vitamin D and neurology threshold Medicine Dementia Cognitive decline lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry older adults business.industry standard Opinion Article medicine.disease Endocrinology medicine.anatomical_structure Nuclear receptor business Neuroscience dementia |
| Zdroj: | Frontiers in Aging Neuroscience Frontiers in Aging Neuroscience, Vol 6 (2014) |
| ISSN: | 1663-4365 |
| DOI: | 10.3389/fnagi.2014.00072 |
| Popis: | Besides its classical function of bone metabolism regulation, vitamin D exhibits multiple biological targets mediated by its nuclear hormone receptor, the vitamin D receptor (VDR) (Holick, 2007; Kalueff and Tuohimaa, 2007; Annweiler et al., 2010a, 2011b). Specific actions on target organs such as the central nervous system (CNS) have been described, providing evidence for a neurosteroid action of vitamin D (Kalueff and Tuohimaa, 2007; Annweiler et al., 2010a). Consistently, older adults with lower serum 25-hydroxyvitamin D (25OHD) concentrations exhibit more often and more severe cognitive decline (Annweiler et al., 2009, 2013a,b; Balion et al., 2012; Etgen et al., 2012). At that point, an important issue to be clarified is to determine what concentration of 25OHD is associated with adverse effects in the brain. |
| Databáze: | OpenAIRE |
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