Prevention and Control of Multidrug-Resistant Gram-Negative Bacteria in Adult Intensive Care Units: A Systematic Review and Network Meta-analysis
| Autor: | Nathorn Chaiyakunapruk, Nattawat Teerawattanapong, Anucha Apisarnthanarak, Piyameth Dilokthornsakul, Kirati Kengkla, Surasak Saokaew |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Acinetobacter baumannii Adult Pediatrics medicine.medical_specialty 030106 microbiology Network Meta-Analysis Cochrane Library Rate ratio law.invention 03 medical and health sciences Young Adult 0302 clinical medicine Randomized controlled trial law Intensive care Drug Resistance Multiple Bacterial medicine Humans 030212 general & internal medicine Clinical Trials as Topic Cross Infection Infection Control biology business.industry Middle Aged biology.organism_classification Intensive care unit Anti-Bacterial Agents Intensive Care Units Infectious Diseases Meta-analysis Pseudomonas aeruginosa Observational study Female business Gram-Negative Bacterial Infections |
| Zdroj: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 64(suppl_2) |
| ISSN: | 1537-6591 |
| Popis: | Background. This study evaluated the relative efficacy of strategies for the prevention of multidrug-resistant gram-negative bacteria (MDR-GNB) in adult intensive care units (ICUs). Methods. A systematic review and network meta-analysis was performed; searches of the Cochrane Library, PubMed, Embase, and CINAHL (Cumulative Index to Nursing and Allied Health Literature) included all randomized controlled trials and observational studies conducted in adult patients hospitalized in ICUs and evaluating standard care (STD), antimicrobial stewardship program (ASP), environmental cleaning (ENV), decolonization methods (DCL), or source control (SCT), simultaneously. The primary outcomes were MDR-GNB acquisition, colonization, and infection; secondary outcome was ICU mortality. Results. Of 3805 publications retrieved, 42 met inclusion criteria (5 randomized controlled trials and 37 observational studies), involving 62 068 patients (median age, 58.8 years; median APACHE [Acute Physiology and Chronic Health Evaluation] II score, 18.9). The majority of studies reported extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae and MDR Acinetobacter baumannii. Compared with STD, a 4-component strategy composed of STD, ASP, ENV, and SCT was the most effective intervention (rate ratio [RR], 0.05 [95% confidence interval {CI}, .01-.38]). When ENV was added to STD+ASP or SCT was added to STD+ENV, there was a significant reduction in the acquisition of MDR A. baumannii (RR, 0.28 [95% CI, .18-.43] and 0.48 [95% CI, .35-.66], respectively). Strategies with ASP as a core component showed a statistically significant reduction the acquisition of ESBLproducing Enterobacteriaceae (RR, 0.28 [95% CI, .11-.69] for STD+ASP+ENV and 0.23 [95% CI, .07-.80] for STD+ASP+DCL). Conclusions. A 4-component strategy was the most effective intervention to prevent MDR-GNB acquisition. As some strategies were differential for certain bacteria, our study highlighted the need for further evaluation of the most effective prevention strategies. |
| Databáze: | OpenAIRE |
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