Replication of avian influenza viruses in humans
Autor: | A. S. Beare, Robert G. Webster |
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Rok vydání: | 1991 |
Předmět: |
Adult
Male animal structures viruses Reassortment Orthomyxoviridae Hemagglutinins Viral Hemagglutinin (influenza) Hemagglutinin Glycoproteins Influenza Virus Antibodies Viral Virus Replication medicine.disease_cause H5N1 genetic structure Virus Microbiology Species Specificity Virology medicine Humans biology virus diseases General Medicine Middle Aged biology.organism_classification Influenza A virus subtype H5N1 Viral replication Influenza A virus biology.protein Female Antibody |
Zdroj: | Archives of Virology. 119:37-42 |
ISSN: | 1432-8798 0304-8608 |
Popis: | Volunteers inoculated with avian influenza viruses belonging to subtypes currently circulating in humans (H1N1 and H3N2) were largely refractory to infection. However 11 out of 40 volunteers inoculated with the avian subtypes, H4N8, H6N1, and H10N7, shed virus and had mild clinical symptoms: they did not produce a detectable antibody response. This was presumably because virus multiplication was limited and insufficient to stimulate a detectable primary immune response. Avian influenza viruses comprise hemagglutinin (HA) subtypes 1-14 and it is possible that HA genes not so far seen in humans could enter the human influenza virus gene pool through reassortment between avian and circulating human viruses. |
Databáze: | OpenAIRE |
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