Kinetics of plasma lysine after oral and parenteral administration to pigs
| Autor: | H. de Visser, J. E. van Dijk, N. P. Lenis, Frans G. M. Russel, L. P. Jager, J. M. F. van Vlissingen, J.G.M. Bakker |
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| Přispěvatelé: | Centraal Instituut voor Voedingsonderzoek TNO Instituut voor Landbouwkundig Onderzoek van Biochemische Produkten TNO |
| Rok vydání: | 1990 |
| Předmět: | |
| Zdroj: | Netherlands Journal of Agricultural Science 38 (1990) 3B Netherlands Journal of Agricultural Science, 38, 623-639 Netherlands Journal of Agricultural Science, 38(3B), 623-639 |
| ISSN: | 0028-2928 |
| DOI: | 10.18174/njas.v38i3b.16583 |
| Popis: | Dutch Landrace X Large White pigs 14 to 15 weeks old and about 45 kg were fed on low-protein diets (16.1%) and supplemented with lysine, orally, by slow or rapid jugular infusion or by slow portal/caval infusion in order to evaluate the bioavailability of lysine with type of treatment. Elimination rate after intravenous treatment had a half-life of 2.0+or-1.6 h (after bolus injection) or 3.7+or-1.9 h (after slow infusion). Absorption of an oral dose of lysine from the intestine (half-life of 3.6+or-0.9 h) was slower than elimination rate (half-life of 0.9+or-0.3 h). No significant liver first-pass effects could be detected and bioavailability of lysine after enteral intake was 82+or-6%. Analysis of plasma kinetics of amino acids may provide a valuable tool to evaluate bioavailability of dietary amino acids. (Abstract retrieved from CAB Abstracts by CABI’s permission) |
| Databáze: | OpenAIRE |
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