High maternal osteocalcin levels during pregnancy is associated with low birth weight infants: A nested case-control study in China
| Autor: | Juan Ye, Jianfeng Xu, Jiarong Tian, Chaoqun Liu, Yaling Huang, Mujun Li, Zengnan Mo, Bangzhu Luo, Ying Luo, Dehao Cao, Shengzhu Huang, Luyun Wei, Chunmei Liang, Xiaobo Yang, Xiujuan Zhu, Qingzhi Hou, Yu Long |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
0301 basic medicine China medicine.medical_specialty Histology Adolescent Physiology Endocrinology Diabetes and Metabolism Osteocalcin 030209 endocrinology & metabolism Logistic regression Young Adult 03 medical and health sciences 0302 clinical medicine Calcitriol Pregnancy Risk Factors medicine Humans biology Obstetrics business.industry Confounding Infant Newborn Gestational age Infant Low Birth Weight medicine.disease Low birth weight 030104 developmental biology Case-Control Studies Nested case-control study biology.protein Gestation Female medicine.symptom business |
| Zdroj: | Bone. 116:35-41 |
| ISSN: | 8756-3282 |
| DOI: | 10.1016/j.bone.2018.07.009 |
| Popis: | Background Low birth weight infants (LBW) are at risk of chronic diseases in later life due to the disorder of energy metabolism during pregnancy. Osteocalcin (OC) has been identified as a hormone that regulate energy metabolism. However, few studies have researched on the associations between maternal serum OC levels and low birth weight infants. Objections To examine the associations between maternal serum OC concentrations and LBW. Methods This was a nested case-control study involving a total of 230 pregnant women delivering LBW and 382 control pregnant women (matched for infant gender, gestational age at blood draw, region of Maternity and Child Healthcare Hospital and maternal age in 1: (1–2) ratio). One serum sample was collected from each pregnant woman at 5–35 weeks' gestation. Pregnant women were divided into 3 groups (1st, 2nd and 3rd trimester group). There were 60 and 142 and 28 pregnant women delivering LBW in the first, second and third trimester, respectively. Similarly, there were 101 and 233 and 48 controls in the first, second and third trimester, respectively. Maternal serum OC and 25(OH)D concentrations were categorized into low and high levels, the low level used as reference in analyses. Binary logistic regression model was used to compute odd radio (ORs) for LBW according to levels of maternal serum OC and 25(OH)D. Results Compared with the subjects in low level in first trimester, LBW was two times as likely to occur among pregnancy women with high serum OC concentrations (OR = 2.04, 95%CI:1.05–3.96). After adjusted for confounding factors, a significant positive relationship still existed (adjusted ORs = 2.29, 95%CI: 1.11–4.72). In second trimester, women in high level of serum OC had nearly 1.6 times the risk of delivering LBW infants as those in the low level (OR = 1.55, 95%CI: 1.01–2.37). After adjusted for confounding factors, the ORs increased (ORs = 1.59, 95%CI:1.03–2.45). No significant associations were found between maternal serum OC levels and LBW in third trimester. In addition, there were no associations between maternal 25(OH)D concentrations and LBW during pregnancy. Conclusion High maternal serum OC levels in the first or the second trimester during pregnancy may be associated with the risk of LBW. |
| Databáze: | OpenAIRE |
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