Evaluation of Turmeric Nanoparticles as Anti-Gout Agent: Modernization of a Traditional Drug
| Autor: | Hamza Rehman, Muhammad Furqan Akhtar, Irum Nawaz, Muhammad Farhan Sohail, Syed Ali Imran Bokhari, Gul Shahnaz, Mubin Mustafa Kiyani, tariq mahmood, Mobina Manzoor |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Gout
02 engineering and technology Pharmacology Kidney Function Tests Antioxidants chemistry.chemical_compound Mice Drug Delivery Systems Liver Function Tests X-Ray Diffraction media_common lcsh:R5-920 0303 health sciences medicine.diagnostic_test Chemistry turmeric General Medicine 021001 nanoscience & nanotechnology lcsh:Medicine (General) 0210 nano-technology Drug inorganic chemicals media_common.quotation_subject monosodium urate crystals Article Gout Suppressants 03 medical and health sciences Nutraceutical Curcuma In vivo medicine Animals Triglycerides 030304 developmental biology Plant Extracts Spectrum Analysis Cholesterol HDL Cholesterol LDL medicine.disease In vitro Dynamic Light Scattering Uric Acid Disease Models Animal nanoparticles gout Uric acid Nanoparticles Lipid profile Liver function tests Phytotherapy |
| Zdroj: | Medicina; Volume 55; Issue 1; Pages: 10 Medicina Medicina, Vol 55, Iss 1, p 10 (2019) Volume 55 Issue 1 |
| ISSN: | 1648-9144 |
| DOI: | 10.3390/medicina55010010 |
| Popis: | Background and objectives: Turmeric has assisted in the control of inflammation and pain for decades and has been used in combination with other nutraceuticals to treat acute and chronic osteoarthritis pain. Recently, the effect of turmeric, turmeric extract, or curcuminoids on musculoskeletal pain, either by themselves or in conjunction with other substances, has been reported. The aim of this study was to develop and characterize turmeric nanoparticles (T-NPs) for various parameters, both in vitro and in vivo. Materials and Methods: The T-NPs were successfully synthesized and characterized using particle size analysis, solubility improvement, SEM, EDX, X-ray diffraction, and in vivo antigout activity in mice model. Results: The T-NPs were of about 46 nm in size with a positive zeta potential +29.55 ± 3.44 and low polydispersity index (PDI) (0.264). Furthermore, the diseased mice, with induced gout via monosodium urate crystals, were treated with 5, 10, and 20 ppm T-NPs, administered orally, and the anti-gout potential was observed through measurement of joint diameter and changes in biochemical parameters, including lipid profile, renal function test, and liver function tests which significantly reduced the levels of these biochemical parameters. Conclusions: Uric acid levels were significantly reduced after the treatment with T-NPs. indicating that T-NPs show superior potential against gout management. Thus, T-NPs can be developed as an efficient antigout agent with minimum toxicities. |
| Databáze: | OpenAIRE |
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