Impact of a Eukaryotic Translation Initiation Factor 3a Polymorphism on Susceptibility to Gastric Cancer

Autor: Zhendong Lei, Lei Sanlin, Yao Hongliang, Kuijie Liu, Hua Zhao
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
Oncology
Male
medicine.medical_specialty
China
Genotype
Health Behavior
Single-nucleotide polymorphism
Prokaryotic Initiation Factor-3
Bioinformatics
Polymerase Chain Reaction
Polymorphism
Single Nucleotide
law.invention
03 medical and health sciences
0302 clinical medicine
Eukaryotic translation
Asian People
law
Risk Factors
Stomach Neoplasms
Internal medicine
medicine
Initiation factor
Humans
Genetic Predisposition to Disease
Gene
Life Style
Polymerase chain reaction
Eukaryotic translation initiation factor 3a
Aged
Aged
80 and over
Original Paper
business.industry
Case-control study
General Medicine
Middle Aged
030104 developmental biology
Socioeconomic Factors
030220 oncology & carcinogenesis
Case-Control Studies
Population study
Female
business
Polymorphisms
Gastric cancer
Zdroj: Medical Principles and Practice
ISSN: 1423-0151
1011-7571
Popis: Objective: To investigate single nucleotide polymorphisms in the eukaryotic translation initiation factor 3a (eIF3a) gene and the risk for gastric cancer within the Chinese population. Subjects and Methods: A total of 322 patients with gastric cancer were selected as the patient group and 340 non-gastric cancer patients were selected as the control group using the case-control method. Polymerase chain reaction-sequence-specific primer technology was leveraged to genotype the rs77382849 single nucleotide polymorphism in the eIF3a gene. The demographic characteristics of the study population and other exposures to risk factors were collected. Unconditional logistic regression analysis was performed to determine the association between the risk factors and gastric cancer. Results: A higher frequency of the eIF3a rs77382849 GG homozygote genotype was observed in the gastric cancer patients compared with the controls (63.98 vs. 54.41%, p < 0.05). After adjustment of exposure risks, such as age, gender, smoking, and drinking, the rs77382849 single nucleotide polymorphism was still associated with susceptibility to gastric cancer. When the eIF3a rs77382849 GG homozygote genotype was used as the reference group, the GA genotype (GA vs. GG: OR = 0.545, 95% CI: 0.386-0.769, p = 0.001) and AA genotype (AA vs. GG: OR = 0.245, 95% CI: 0.072-0.836, p = 0.025) were both correlated with a significantly decreased risk for gastric cancer development. Conclusion: An association between eIF3a rs77382849 polymorphism and susceptibility to gastric cancer was observed in these Chinese patients.
Databáze: OpenAIRE
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