Does Bombesin-like Peptide Mediate Radiation-induced Anorexia and Satiety?
| Autor: | Lars Franzén, Uno Kjörell, Yan Aalto, Ulrika Funegård, Sture Forsgren, Roger Henriksson |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
Saliva Radioimmunoassay Satiation Salivary Glands Rats Sprague-Dawley chemistry.chemical_compound fluids and secretions stomatognathic system Internal medicine Parenchyma medicine Animals Radiology Nuclear Medicine and imaging Radiotherapy Salivary gland business.industry Bombesin Hematology General Medicine Immunohistochemistry Anorexia Rats medicine.anatomical_structure Endocrinology Gastrin-Releasing Peptide Oncology chemistry Bombesin-like peptides Female business hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Acta Oncologica. 38:1099-1102 |
| ISSN: | 1651-226X 0284-186X |
| DOI: | 10.1080/028418699432428 |
| Popis: | Bombesin (BN) and its mammalian counterpart gastrin-releasing peptide (GRP) act as neuroregulatory hormones and peripheral and central satiety-inducing agents. Previously, we demonstrated that irradiation induces an increase in the expression of BN/GRP in the innervation of the salivary glands in rats. We therefore carried out a study using radioimmunoassay (RIA) analysis and immunohistochemistry to examine whether saliva contains BN and whether irradiation affects the BN release to saliva in rats. Immunoreactivity for BN was detected not only in the innervation of the parenchyma but also in the duct cells and in the lumina of the ducts, suggesting entrance of BN into saliva. The RIA analysis confirmed that rat saliva contains a BN-like peptide. The observation shows that saliva contains this peptide but that there is no significant increase following the radiation schedule used. Nevertheless, the occurrence of an enhanced expression of BN in different peripheral tissues such as the salivary and laryngeal glands should be taken into consideration when discussing the clinically important problem of reduced food intake and anorexia in cancer patients. |
| Databáze: | OpenAIRE |
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