New natural agonists of the transient receptor potential Ankyrin 1 (TRPA1) channel
| Autor: | Carole de Senarclens-Bezençon, Stephanie Michlig, Jenny Meylan Merlini, Coline Legrand |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Agonist Molecular biology medicine.drug_class TRPV Cation Channels lcsh:Medicine CHO Cells Pharmacology Transfection Article Cinnamaldehyde 03 medical and health sciences chemistry.chemical_compound Transient receptor potential channel Cricetulus 0302 clinical medicine Chemesthesis Ganglia Spinal medicine Animals Acrolein lcsh:Science TRPA1 Cation Channel Neurons Aldehydes Multidisciplinary lcsh:R food and beverages Chemical biology 030104 developmental biology chemistry Adipogenesis Benzaldehydes Cymenes Cuminaldehyde lcsh:Q Single-Cell Analysis Transduction (physiology) psychological phenomena and processes 030217 neurology & neurosurgery Function (biology) |
| Zdroj: | Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020) Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-020-68013-2 |
| Popis: | The transient receptor potential (TRP) channels family are cationic channels involved in various physiological processes as pain, inflammation, metabolism, swallowing function, gut motility, thermoregulation or adipogenesis. In the oral cavity, TRP channels are involved in chemesthesis, the sensory chemical transduction of spicy ingredients. Among them, TRPA1 is activated by natural molecules producing pungent, tingling or irritating sensations during their consumption. TRPA1 can be activated by different chemicals found in plants or spices such as the electrophiles isothiocyanates, thiosulfinates or unsaturated aldehydes. TRPA1 has been as well associated to various physiological mechanisms like gut motility, inflammation or pain. Cinnamaldehyde, its well known potent agonist from cinnamon, is reported to impact metabolism and exert anti-obesity and anti-hyperglycemic effects. Recently, a structurally similar molecule to cinnamaldehyde, cuminaldehyde was shown to possess anti-obesity and anti-hyperglycemic effect as well. We hypothesized that both cinnamaldehyde and cuminaldehyde might exert this metabolic effects through TRPA1 activation and evaluated the impact of cuminaldehyde on TRPA1. The results presented here show that cuminaldehyde activates TRPA1 as well. Additionally, a new natural agonist of TRPA1, tiglic aldehyde, was identified and p-anisaldehyde confirmed. |
| Databáze: | OpenAIRE |
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