Effect of MGHPPGP Peptide Administered during the Post-Traumatic Period on Morphometric Parameters of the Neocortex and Hippocampus, Hepatocytes, and Epithelium of the Tongue and Small Intestine in Rats
| Autor: | N. Yu. Yakusheva, A. A. Innokentiev, M. Yu. Fleishman, Yu. B. Malofey, I. V. Tolstenok |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Pathology medicine.medical_specialty Traumatic brain injury Hippocampus Neocortex Biology Hippocampal formation General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Tongue Parietal Lobe Brain Injuries Traumatic Intestine Small medicine Animals Rats Wistar CA1 Region Hippocampal Neurons Epithelial Cells General Medicine medicine.disease Small intestine Epithelium Staining Rats Disease Models Animal 030104 developmental biology medicine.anatomical_structure Neuroprotective Agents Liver Hepatocytes Oligopeptides 030217 neurology & neurosurgery Injections Intraperitoneal |
| Zdroj: | Bulletin of experimental biology and medicine. 168(4) |
| ISSN: | 1573-8221 |
| Popis: | The effect of glyproline-containing peptide MGHPPGP (Met-Glu-His-Phe-Pro-Gly-Pro) was studied in experiments on male Wistar rats with modeled traumatic brain injury. The peptide was administered intraperitoneally in a dose of 1 mg/kg in 3 h and on days 2, 3, 4, 5 after injury. We evaluated morphometric parameters of the epithelial cells of the tongue, small intestine, and liver cells (AgNOR staining), neuronal layers II and V of the neocortex of the parietal lobe and hippocampal CA1 field (staining with gallocyanin) were evaluated in the post-traumatic period. Traumatic brain injury (TBI) was induced in rats by using the impact model (WDM; weight drop method). MGHPPGP peptide corrected the activity indicators of the nuclear organizer regions in epitheliocytes of the tongue. |
| Databáze: | OpenAIRE |
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