Glk: a locus controlling galactokinase activity in the mouse
| Autor: | J. D. Mishkin, B. A. Taylor, W. J. Mellman |
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| Rok vydání: | 1976 |
| Předmět: |
C57BL/6
Locus (genetics) Mice Inbred Strains Biochemistry BALB/c Mice Inbred strain Species Specificity Genotype Genetics Animals Allele Molecular Biology Ecology Evolution Behavior and Systematics Alleles Crosses Genetic Recombination Genetic biology Phosphotransferases Galactose Genetic Variation General Medicine biology.organism_classification Galactokinase Hybridization Genetic Galactokinase activity |
| Zdroj: | Biochemical genetics. 14(7-8) |
| ISSN: | 0006-2928 |
| Popis: | Inbred strains of mice exhibit significant variation in whole blood galactokinase (GALK) activity. Activities tend to cluster into two classes, one class having approximately twice the activity of the other. Hybrids (F1) between “high” and “low” strains have activity intermediate between the parental activities. Two sets of recombinant inbred (RI) lines were developed by brother-sister mating, beginning with F2 generations of crosses between different pairs of high and low GALK activity strains. The RI lines segregated in terms of GALK activity, indicating single gene inheritance; this galactokinase locus has been designated Glk. The strain distribution patterns of both RI series agreed closely with esterase-3 (Es-3) alleles of the respective parental strains (31/34 independently derived strains were concordant for Es-3 and Glk genotypes), a finding consistent with a map distance between loci of 2.5 cM. Es-3 has been located on the distal end of chromosome 11. Glk, with its alleles Glk a (lower activity) and Glk b (higher activity), is therefore assigned to the same region. |
| Databáze: | OpenAIRE |
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