Low mannose-binding lectin and increased complement activation correlate to allograft vasculopathy, ischaemia, and rejection after human heart transplantation
| Autor: | Knut Endresen, Ragnhild Wergeland, Svein Simonsen, Tom Eirik Mollnes, Odd Geiran, Lars Gullestad, Arnt E. Fiane, Arne K. Andreassen, Pa L Aukrust, Lars Heggelund, Guttorm Haraldsen, Stig S. Frøland, Helge Scott, Thor Ueland |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Graft Rejection Male medicine.medical_specialty medicine.medical_treatment Myocardial Ischemia Coronary Artery Disease Mannose-Binding Lectin Gastroenterology Endothelial activation Coronary artery disease Internal medicine medicine Humans Transplantation Homologous Prospective Studies Complement Activation Mannan-binding lectin Heart transplantation Vascular disease business.industry Middle Aged medicine.disease MBL deficiency Complement system Transplantation Immunology Heart Transplantation Female E-Selectin Cardiology and Cardiovascular Medicine business Biomarkers Follow-Up Studies |
| Zdroj: | European Heart Journal. 26:1660-1665 |
| ISSN: | 1522-9645 0195-668X |
| DOI: | 10.1093/eurheartj/ehi198 |
| Popis: | Aims Transplant-associated coronary artery disease (TxCAD) is a major cause of post-transplant graft failure. The aim of this study was to investigate a possible role of mannose-binding lectin (MBL) deficiency and complement activation in TxCAD. Methods and results In a prospective study of heart transplant recipients ( n =38) with a follow-up of 5.3±1.3 years (range: 0.9–6.6), angiographically verified TxCAD ( n =6) was correlated to plasma MBL, complement activation, and endothelial activation (soluble E-selectin). MBL deficiency ( |
| Databáze: | OpenAIRE |
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